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The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.
Neurobiol Aging. 2009 May; 30(5):672-81.NA

Abstract

While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study.

Authors+Show Affiliations

New York University School of Medicine, New York, NY 10016, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17920160

Citation

Glodzik-Sobanska, Lidia, et al. "The Effects of Normal Aging and ApoE Genotype On the Levels of CSF Biomarkers for Alzheimer's Disease." Neurobiology of Aging, vol. 30, no. 5, 2009, pp. 672-81.
Glodzik-Sobanska L, Pirraglia E, Brys M, et al. The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiol Aging. 2009;30(5):672-81.
Glodzik-Sobanska, L., Pirraglia, E., Brys, M., de Santi, S., Mosconi, L., Rich, K. E., Switalski, R., Saint Louis, L., Sadowski, M. J., Martiniuk, F., Mehta, P., Pratico, D., Zinkowski, R. P., Blennow, K., & de Leon, M. J. (2009). The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiology of Aging, 30(5), 672-81.
Glodzik-Sobanska L, et al. The Effects of Normal Aging and ApoE Genotype On the Levels of CSF Biomarkers for Alzheimer's Disease. Neurobiol Aging. 2009;30(5):672-81. PubMed PMID: 17920160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. AU - Glodzik-Sobanska,Lidia, AU - Pirraglia,Elizabeth, AU - Brys,Miroslaw, AU - de Santi,Susan, AU - Mosconi,Lisa, AU - Rich,Kenneth E, AU - Switalski,Remigiusz, AU - Saint Louis,Leslie, AU - Sadowski,Martin J, AU - Martiniuk,Frank, AU - Mehta,Pankaj, AU - Pratico,Domenico, AU - Zinkowski,Raymond P, AU - Blennow,Kaj, AU - de Leon,Mony J, Y1 - 2007/10/24/ PY - 2007/05/08/received PY - 2007/08/10/revised PY - 2007/08/17/accepted PY - 2007/10/9/pubmed PY - 2009/6/23/medline PY - 2007/10/9/entrez SP - 672 EP - 81 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 30 IS - 5 N2 - While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/17920160/The_effects_of_normal_aging_and_ApoE_genotype_on_the_levels_of_CSF_biomarkers_for_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(07)00349-1 DB - PRIME DP - Unbound Medicine ER -