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Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid.
J Dermatol Sci. 2008 Feb; 49(2):153-61.JD

Abstract

BACKGROUND

Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins, BP180 and BP230. NC16A, a non-collagenous stretch of the BP180 ectodomain is the primary target of pathogenic IgG antibodies. Whereas IgG anti-BP180 autoantibodies play a primary role in the pathogenesis, there is a growing number of data regarding the potential pathogenic roles of IgE class autoantibodies in BP.

OBJECTIVES

To examine the levels of IgG and IgE autoantibodies against BP180 and BP230, and to investigate mutual association and clinical relevance.

METHODS

Sera obtained from 67BP patients and 36 healthy donors were subjected to ELISA assays to measure serum IgG and IgE levels of anti-BP180 and anti-BP230 antibodies.

RESULTS

IgG anti-BP180 antibodies were positive in 63 (94%) of 67BP patients. IgG anti-BP230, IgE anti-BP180, and IgE anti-BP230 antibodies were found in 48 (72%), 20 (30%) and 45 (67%), respectively. IgG anti-BP180 levels were correlated with the affected areas. IgG anti-BP230 antibodies tended to increase in proportion to elongation of disease duration. IgE anti-BP230 levels showed a strong association with local eosinophil accumulation, while the levels were reversely related with the affected areas in BP.

CONCLUSIONS

IgE autoantibodies to BP180 and BP230 are detected at high frequencies in BP. IgE anti-BP230 antibodies may have a role in attracting eosinophils to the skin lesions.

Authors+Show Affiliations

Department of Dermatology, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17920818

Citation

Ishiura, Nobuko, et al. "Serum Levels of IgE anti-BP180 and anti-BP230 Autoantibodies in Patients With Bullous Pemphigoid." Journal of Dermatological Science, vol. 49, no. 2, 2008, pp. 153-61.
Ishiura N, Fujimoto M, Watanabe R, et al. Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. J Dermatol Sci. 2008;49(2):153-61.
Ishiura, N., Fujimoto, M., Watanabe, R., Nakashima, H., Kuwano, Y., Yazawa, N., Echigo, T., Okochi, H., & Tamaki, K. (2008). Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Journal of Dermatological Science, 49(2), 153-61.
Ishiura N, et al. Serum Levels of IgE anti-BP180 and anti-BP230 Autoantibodies in Patients With Bullous Pemphigoid. J Dermatol Sci. 2008;49(2):153-61. PubMed PMID: 17920818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. AU - Ishiura,Nobuko, AU - Fujimoto,Manabu, AU - Watanabe,Rei, AU - Nakashima,Hiroko, AU - Kuwano,Yoshihiro, AU - Yazawa,Norihito, AU - Echigo,Takeshi, AU - Okochi,Hitoshi, AU - Tamaki,Kunihiko, Y1 - 2007/10/24/ PY - 2007/04/09/received PY - 2007/08/20/revised PY - 2007/08/25/accepted PY - 2007/10/9/pubmed PY - 2008/3/7/medline PY - 2007/10/9/entrez SP - 153 EP - 61 JF - Journal of dermatological science JO - J Dermatol Sci VL - 49 IS - 2 N2 - BACKGROUND: Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins, BP180 and BP230. NC16A, a non-collagenous stretch of the BP180 ectodomain is the primary target of pathogenic IgG antibodies. Whereas IgG anti-BP180 autoantibodies play a primary role in the pathogenesis, there is a growing number of data regarding the potential pathogenic roles of IgE class autoantibodies in BP. OBJECTIVES: To examine the levels of IgG and IgE autoantibodies against BP180 and BP230, and to investigate mutual association and clinical relevance. METHODS: Sera obtained from 67BP patients and 36 healthy donors were subjected to ELISA assays to measure serum IgG and IgE levels of anti-BP180 and anti-BP230 antibodies. RESULTS: IgG anti-BP180 antibodies were positive in 63 (94%) of 67BP patients. IgG anti-BP230, IgE anti-BP180, and IgE anti-BP230 antibodies were found in 48 (72%), 20 (30%) and 45 (67%), respectively. IgG anti-BP180 levels were correlated with the affected areas. IgG anti-BP230 antibodies tended to increase in proportion to elongation of disease duration. IgE anti-BP230 levels showed a strong association with local eosinophil accumulation, while the levels were reversely related with the affected areas in BP. CONCLUSIONS: IgE autoantibodies to BP180 and BP230 are detected at high frequencies in BP. IgE anti-BP230 antibodies may have a role in attracting eosinophils to the skin lesions. SN - 0923-1811 UR - https://www.unboundmedicine.com/medline/citation/17920818/Serum_levels_of_IgE_anti_BP180_and_anti_BP230_autoantibodies_in_patients_with_bullous_pemphigoid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-1811(07)00309-X DB - PRIME DP - Unbound Medicine ER -