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Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up.
Br J Neurosurg. 2007 Oct; 21(5):504-9.BJ

Abstract

Deep brain stimulation (DBS) of the nucleus ventralis intermedius thalami (Vim) in the treatment of essential tremor (ET) is well documented concerning the acute effects. Reports of the long-term effects are, however, few and the aim of the present study was to analyse the long-term efficacy of this treatment. Nineteen patients operated with unilateral Vim-DBS were evaluated with the Essential Tremor Rating Scale (ETRS) before surgery, and after a mean time of 1 and 7 years after surgery. The ETRS score for tremor of the contralateral hand was reduced from 6.8 at baseline to 1.2 and 2.7, respectively, on stimulation at follow-up. For hand function (item 11 - 14) the score was reduced from 12.7 to 4.1 and 8.2, respectively. Vim-DBS is an efficient treatment for ET, also after many years of treatment. There is, however, a decreasing effect over time, most noticeable concerning tremor of action.

Authors+Show Affiliations

Department of Neurosurgery, University Hospital of Umeå, Umeå, Sweden. patric.blomstedt@neuro.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17922323

Citation

Blomstedt, P, et al. "Thalamic Deep Brain Stimulation in the Treatment of Essential Tremor: a Long-term Follow-up." British Journal of Neurosurgery, vol. 21, no. 5, 2007, pp. 504-9.
Blomstedt P, Hariz GM, Hariz MI, et al. Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up. Br J Neurosurg. 2007;21(5):504-9.
Blomstedt, P., Hariz, G. M., Hariz, M. I., & Koskinen, L. O. (2007). Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up. British Journal of Neurosurgery, 21(5), 504-9.
Blomstedt P, et al. Thalamic Deep Brain Stimulation in the Treatment of Essential Tremor: a Long-term Follow-up. Br J Neurosurg. 2007;21(5):504-9. PubMed PMID: 17922323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up. AU - Blomstedt,P, AU - Hariz,G-M, AU - Hariz,M I, AU - Koskinen,L-O D, PY - 2007/10/9/pubmed PY - 2008/4/12/medline PY - 2007/10/9/entrez SP - 504 EP - 9 JF - British journal of neurosurgery JO - Br J Neurosurg VL - 21 IS - 5 N2 - Deep brain stimulation (DBS) of the nucleus ventralis intermedius thalami (Vim) in the treatment of essential tremor (ET) is well documented concerning the acute effects. Reports of the long-term effects are, however, few and the aim of the present study was to analyse the long-term efficacy of this treatment. Nineteen patients operated with unilateral Vim-DBS were evaluated with the Essential Tremor Rating Scale (ETRS) before surgery, and after a mean time of 1 and 7 years after surgery. The ETRS score for tremor of the contralateral hand was reduced from 6.8 at baseline to 1.2 and 2.7, respectively, on stimulation at follow-up. For hand function (item 11 - 14) the score was reduced from 12.7 to 4.1 and 8.2, respectively. Vim-DBS is an efficient treatment for ET, also after many years of treatment. There is, however, a decreasing effect over time, most noticeable concerning tremor of action. SN - 0268-8697 UR - https://www.unboundmedicine.com/medline/citation/17922323/Thalamic_deep_brain_stimulation_in_the_treatment_of_essential_tremor:_a_long_term_follow_up_ L2 - https://www.tandfonline.com/doi/full/10.1080/02688690701552278 DB - PRIME DP - Unbound Medicine ER -