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Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life.
J Infect Dis. 2007 Nov 01; 196(9):1339-45.JI

Abstract

BACKGROUND

Measles remains an important cause of death worldwide, and vaccinating individuals at an earlier age could lead to better control of the disease. However, persistence of maternal antibody and young age affect the quantity of vaccine-induced neutralizing antibody and may also affect antibody quality.

METHODS

Enzyme immunoassay was used to analyze measles virus-specific IgG levels, avidity maturation, and isotype changes, using serum samples from infants who received measles vaccine at 6 months of age and measles-mumps-rubella (MMR)-II at 12 months of age (n=26), measles vaccine at 9 months of age and measles-mumps-rubella (MMR)-II at 12 months of age (n=48), or only MMR-II at 12 months of age (n=27).

RESULTS

The median IgG level was lower among infants with maternal antibody than among those without maternal antibody. Compared with median avidity indices for infants aged 12 months, median values were lower for 6-month-old infants with maternal antibody (P=.0001), 6-month-old infants without maternal antibody (P=.001), 9-month-old infants with maternal antibody (P=.03), and 9-month-old infants without maternal antibody (P=.006). The median IgG3 level was highest at 6 months of age. IgG1 was predominant at 12 months. Low avidity responses at 6 or 9 months of age did not hinder higher avidity responses or the switch to IgG1 after secondary vaccination. The 2-dose regimen did not augment the response, compared with the response in infants who received 1 dose at 12 months of age.

CONCLUSIONS

Avidity and isotype maturation of measles vaccine-induced antibody are affected by age, providing insight into the ontogeny of the immune response to measles vaccine.

Authors+Show Affiliations

W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17922398

Citation

Nair, Nitya, et al. "Age-dependent Differences in IgG Isotype and Avidity Induced By Measles Vaccine Received During the First Year of Life." The Journal of Infectious Diseases, vol. 196, no. 9, 2007, pp. 1339-45.
Nair N, Gans H, Lew-Yasukawa L, et al. Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. J Infect Dis. 2007;196(9):1339-45.
Nair, N., Gans, H., Lew-Yasukawa, L., Long-Wagar, A. C., Arvin, A., & Griffin, D. E. (2007). Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. The Journal of Infectious Diseases, 196(9), 1339-45.
Nair N, et al. Age-dependent Differences in IgG Isotype and Avidity Induced By Measles Vaccine Received During the First Year of Life. J Infect Dis. 2007 Nov 1;196(9):1339-45. PubMed PMID: 17922398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. AU - Nair,Nitya, AU - Gans,Hayley, AU - Lew-Yasukawa,Linda, AU - Long-Wagar,Andrea C, AU - Arvin,Ann, AU - Griffin,Diane E, Y1 - 2007/10/02/ PY - 2006/12/03/received PY - 2007/05/21/accepted PY - 2007/10/9/pubmed PY - 2007/12/8/medline PY - 2007/10/9/entrez SP - 1339 EP - 45 JF - The Journal of infectious diseases JO - J Infect Dis VL - 196 IS - 9 N2 - BACKGROUND: Measles remains an important cause of death worldwide, and vaccinating individuals at an earlier age could lead to better control of the disease. However, persistence of maternal antibody and young age affect the quantity of vaccine-induced neutralizing antibody and may also affect antibody quality. METHODS: Enzyme immunoassay was used to analyze measles virus-specific IgG levels, avidity maturation, and isotype changes, using serum samples from infants who received measles vaccine at 6 months of age and measles-mumps-rubella (MMR)-II at 12 months of age (n=26), measles vaccine at 9 months of age and measles-mumps-rubella (MMR)-II at 12 months of age (n=48), or only MMR-II at 12 months of age (n=27). RESULTS: The median IgG level was lower among infants with maternal antibody than among those without maternal antibody. Compared with median avidity indices for infants aged 12 months, median values were lower for 6-month-old infants with maternal antibody (P=.0001), 6-month-old infants without maternal antibody (P=.001), 9-month-old infants with maternal antibody (P=.03), and 9-month-old infants without maternal antibody (P=.006). The median IgG3 level was highest at 6 months of age. IgG1 was predominant at 12 months. Low avidity responses at 6 or 9 months of age did not hinder higher avidity responses or the switch to IgG1 after secondary vaccination. The 2-dose regimen did not augment the response, compared with the response in infants who received 1 dose at 12 months of age. CONCLUSIONS: Avidity and isotype maturation of measles vaccine-induced antibody are affected by age, providing insight into the ontogeny of the immune response to measles vaccine. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/17922398/Age_dependent_differences_in_IgG_isotype_and_avidity_induced_by_measles_vaccine_received_during_the_first_year_of_life_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/522519 DB - PRIME DP - Unbound Medicine ER -