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[Dyslipidemia and the risk of kidney disease].
G Ital Nefrol. 2007 Sep-Oct; 24 Suppl 38:8-12.GI

Abstract

An abnormal lipid profile is very frequent in patients with kidney disease due to the well-known nephrotoxicity of lipids. During progression of chronic kidney disease, the excretion of triglycerides, LDL and proteins increases while the glomerular filtration rate declines. Blood lipoproteins and lipids are modulated depending on the type of treatment: hemodialysis, CAPD or renal transplant. We analyzed many studies on dyslipidemia in patients with kidney disease by comparing different therapies. The use of statins reduces protein excretion and hyperlipidemia as well as progression of chronic renal failure with a direct effect on mesangial cell proliferation. A decrease in total cholesterol and LDL occurs in hemodialysis patients, a decrease in LDL and an increase in HDL occur in CAPD patients, and a decrease in LDL and triglycerides is observed in renal transplant recipients; in the latter, graft survival increases without there being any relevant correlation with immunosuppressive treatment. In conclusion, we found that statins are useful to contrast the progression of chronic kidney disease and atherosclerosis in hemodialysis and CAPD patients and to reduce chronic allograft nephropathy in renal transplant recipients.

Authors+Show Affiliations

Ligabue G
Divisione di Nefrologia Dialisi e Trapianto Renale, Azienda Ospedaliero Universitaria di Modena, Università degli Studi di Modena e Reggio Emilia, Modena, Italy.
Cavazzini F
No affiliation info available
Albertazzi A
No affiliation info available

MeSH

BiomarkersCholesterolCholesterol, LDLDisease ProgressionDyslipidemiasEvidence-Based MedicineGlomerular Filtration RateHumansHydroxymethylglutaryl-CoA Reductase InhibitorsKidney DiseasesKidney Failure, ChronicKidney TransplantationLipoproteinsRenal DialysisRisk FactorsTreatment OutcomeTriglycerides

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

17922441

Citation

Ligabue, G, et al. "[Dyslipidemia and the Risk of Kidney Disease]." Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia, vol. 24 Suppl 38, 2007, pp. 8-12.
Ligabue G, Cavazzini F, Albertazzi A. [Dyslipidemia and the risk of kidney disease]. G Ital Nefrol. 2007;24 Suppl 38:8-12.
Ligabue, G., Cavazzini, F., & Albertazzi, A. (2007). [Dyslipidemia and the risk of kidney disease]. Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia, 24 Suppl 38, 8-12.
Ligabue G, Cavazzini F, Albertazzi A. [Dyslipidemia and the Risk of Kidney Disease]. G Ital Nefrol. 2007 Sep-Oct;24 Suppl 38:8-12. PubMed PMID: 17922441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dyslipidemia and the risk of kidney disease]. AU - Ligabue,G, AU - Cavazzini,F, AU - Albertazzi,A, PY - 2007/12/6/pubmed PY - 2010/3/6/medline PY - 2007/12/6/entrez SP - 8 EP - 12 JF - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia JO - G Ital Nefrol VL - 24 Suppl 38 N2 - An abnormal lipid profile is very frequent in patients with kidney disease due to the well-known nephrotoxicity of lipids. During progression of chronic kidney disease, the excretion of triglycerides, LDL and proteins increases while the glomerular filtration rate declines. Blood lipoproteins and lipids are modulated depending on the type of treatment: hemodialysis, CAPD or renal transplant. We analyzed many studies on dyslipidemia in patients with kidney disease by comparing different therapies. The use of statins reduces protein excretion and hyperlipidemia as well as progression of chronic renal failure with a direct effect on mesangial cell proliferation. A decrease in total cholesterol and LDL occurs in hemodialysis patients, a decrease in LDL and an increase in HDL occur in CAPD patients, and a decrease in LDL and triglycerides is observed in renal transplant recipients; in the latter, graft survival increases without there being any relevant correlation with immunosuppressive treatment. In conclusion, we found that statins are useful to contrast the progression of chronic kidney disease and atherosclerosis in hemodialysis and CAPD patients and to reduce chronic allograft nephropathy in renal transplant recipients. SN - 0393-5590 UR - https://www.unboundmedicine.com/medline/citation/17922441/[Dyslipidemia_and_the_risk_of_kidney_disease]_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -