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Evaluation of circulating natural type 1 interferon-producing cells in HIV/GBV-C and HIV/HCV coinfected patients: a preliminary study.
Arch Med Res. 2007 Nov; 38(8):868-75.AM

Abstract

BACKGROUND

GB virus-C (GBV-C) is a flavivirus that probably influences HIV infection-associated disease among HIV/GBV-C coinfected patients and inhibits the progression of HIV infection to AIDS. To address the possibility of immune-modulating effects of GBV-C coinfection in HIV patients, we evaluated interferon-producing cells in HIV/GBV-C coinfected patients and compared them to HIV-infected patients.

METHODS

We performed a pilot study to enumerate interferon-producing cell count by two-color flow cytometric analysis and also for determining the frequency of ongoing GBV-C and HCV infection among patients infected with HIV. Then, 83 asymptomatic HIV-positive patients were considered for evaluation of interferon-producing cells. Eighty three patients were stratified in four groups according to the HCV and GBV-C infection status: patients infected with HCV and GBV-C (GBV-C+/HCV+), patients infected with GBV-C but not with HCV (GBV-C+/HCV-), patients infected with HCV but not with GBV-C (GBV-C-/HCV+), and patients not infected by GBV-C and HCV (GBV-C-/HCV-).

RESULTS

GBV-C was detected in plasma samples from 15.5% of HIV-infected patients and the frequency of HCV infection was 47.5%. Interferon-producing cells in GBV-C coinfected individuals revealed a wider range of numbers; however, there was no significant difference in the interferon-producing cell count among HIV-infected individuals.

CONCLUSIONS

It does not appear that GBV-C coinfection affects generation or redistribution of interferon-producing cells in HIV-infected patients with relatively intact immune system.

Authors+Show Affiliations

Department of Immunology, School of Medicine, Tarbiat Modarres University, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17923269

Citation

Haji Molla Hoseini, Mostafa, et al. "Evaluation of Circulating Natural Type 1 Interferon-producing Cells in HIV/GBV-C and HIV/HCV Coinfected Patients: a Preliminary Study." Archives of Medical Research, vol. 38, no. 8, 2007, pp. 868-75.
Haji Molla Hoseini M, Pourfathollah AA, Mohraz M, et al. Evaluation of circulating natural type 1 interferon-producing cells in HIV/GBV-C and HIV/HCV coinfected patients: a preliminary study. Arch Med Res. 2007;38(8):868-75.
Haji Molla Hoseini, M., Pourfathollah, A. A., Mohraz, M., Soheili, Z., Amini, S., Aghaiepour, M., Samiee, S., Nikoogoftar, M., & Meshkani, R. (2007). Evaluation of circulating natural type 1 interferon-producing cells in HIV/GBV-C and HIV/HCV coinfected patients: a preliminary study. Archives of Medical Research, 38(8), 868-75.
Haji Molla Hoseini M, et al. Evaluation of Circulating Natural Type 1 Interferon-producing Cells in HIV/GBV-C and HIV/HCV Coinfected Patients: a Preliminary Study. Arch Med Res. 2007;38(8):868-75. PubMed PMID: 17923269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of circulating natural type 1 interferon-producing cells in HIV/GBV-C and HIV/HCV coinfected patients: a preliminary study. AU - Haji Molla Hoseini,Mostafa, AU - Pourfathollah,Ali-Akbar, AU - Mohraz,Minoo, AU - Soheili,Zahra, AU - Amini,Sedigheh, AU - Aghaiepour,Mahnaz, AU - Samiee,Shahram, AU - Nikoogoftar,Mahin, AU - Meshkani,Reza, Y1 - 2007/08/24/ PY - 2007/02/06/received PY - 2007/05/21/accepted PY - 2007/10/10/pubmed PY - 2007/12/6/medline PY - 2007/10/10/entrez SP - 868 EP - 75 JF - Archives of medical research JO - Arch Med Res VL - 38 IS - 8 N2 - BACKGROUND: GB virus-C (GBV-C) is a flavivirus that probably influences HIV infection-associated disease among HIV/GBV-C coinfected patients and inhibits the progression of HIV infection to AIDS. To address the possibility of immune-modulating effects of GBV-C coinfection in HIV patients, we evaluated interferon-producing cells in HIV/GBV-C coinfected patients and compared them to HIV-infected patients. METHODS: We performed a pilot study to enumerate interferon-producing cell count by two-color flow cytometric analysis and also for determining the frequency of ongoing GBV-C and HCV infection among patients infected with HIV. Then, 83 asymptomatic HIV-positive patients were considered for evaluation of interferon-producing cells. Eighty three patients were stratified in four groups according to the HCV and GBV-C infection status: patients infected with HCV and GBV-C (GBV-C+/HCV+), patients infected with GBV-C but not with HCV (GBV-C+/HCV-), patients infected with HCV but not with GBV-C (GBV-C-/HCV+), and patients not infected by GBV-C and HCV (GBV-C-/HCV-). RESULTS: GBV-C was detected in plasma samples from 15.5% of HIV-infected patients and the frequency of HCV infection was 47.5%. Interferon-producing cells in GBV-C coinfected individuals revealed a wider range of numbers; however, there was no significant difference in the interferon-producing cell count among HIV-infected individuals. CONCLUSIONS: It does not appear that GBV-C coinfection affects generation or redistribution of interferon-producing cells in HIV-infected patients with relatively intact immune system. SN - 0188-4409 UR - https://www.unboundmedicine.com/medline/citation/17923269/Evaluation_of_circulating_natural_type_1_interferon_producing_cells_in_HIV/GBV_C_and_HIV/HCV_coinfected_patients:_a_preliminary_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(07)00237-8 DB - PRIME DP - Unbound Medicine ER -