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[Increased nitric oxide levels in peritoneal fluids of minor-endometriosis patients and its relation to IVF-ET outcomes].

Abstract

OBJECTIVE

To investigate the role of nitric oxide (NO) in the pathogenesis of early endometriosis-associated infertility.

METHODS

The volume of peritoneal fluids was recorded and the concentration of NO in peritoneal fluid and serum was measured with a fluorescence method using 4, 5-diaminofluorescein (DAF-2) as an indicator, in 60 patients with early endometriosis-associated infertility (endometriosis group), 60 patients with tubal infertility (tubal infertility group) and 20 patients without infertility (control group). The IVF-ET outcomes between patients with endometriosis and tubal infertility were compared.

RESULT

The volume of peritoneal fluids from endometriosis group patients increased significantly compared with that in tubal infertility group patients and control groups. The concentration of NO in peritoneal fluid of the control group,the tubal infertility group and the endometriosis group was 9.98, 13.76 and 20.72, respectively (P<0.017). Furthermore the concentration of NO in serum of the patients of control group,tubal infertility group and endometriosis group was 12.25, 13.00, 13.60, respectively; there were no significant differences among these three groups. There were no significant differences in implantation rate, pregnancy rate and abortion rate of IVF-ET between endometriosis group patients and tubal infertility group patients. However, the fertilization rate was significantly lower in endometriosis group patients than that in tubal infertility group patients.

CONCLUSION

Changes of nitric oxide in peritoneal fluids may play an important role in the pathogenesis of early endometriosis-associated infertility and IVF-ET may serve as an alternative method for this type of infertility.

Authors+Show Affiliations

Department of Reproduction Endocrinology, The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17924457

Citation

Luo, Qiong, et al. "[Increased Nitric Oxide Levels in Peritoneal Fluids of Minor-endometriosis Patients and Its Relation to IVF-ET Outcomes]." Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, vol. 36, no. 5, 2007, pp. 424-8.
Luo Q, Dong LJ, Huang HF. [Increased nitric oxide levels in peritoneal fluids of minor-endometriosis patients and its relation to IVF-ET outcomes]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007;36(5):424-8.
Luo, Q., Dong, L. J., & Huang, H. F. (2007). [Increased nitric oxide levels in peritoneal fluids of minor-endometriosis patients and its relation to IVF-ET outcomes]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 36(5), pp. 424-8.
Luo Q, Dong LJ, Huang HF. [Increased Nitric Oxide Levels in Peritoneal Fluids of Minor-endometriosis Patients and Its Relation to IVF-ET Outcomes]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007;36(5):424-8. PubMed PMID: 17924457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Increased nitric oxide levels in peritoneal fluids of minor-endometriosis patients and its relation to IVF-ET outcomes]. AU - Luo,Qiong, AU - Dong,Li-jun, AU - Huang,He-feng, PY - 2007/10/10/pubmed PY - 2008/5/15/medline PY - 2007/10/10/entrez SP - 424 EP - 8 JF - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences JO - Zhejiang Da Xue Xue Bao Yi Xue Ban VL - 36 IS - 5 N2 - OBJECTIVE: To investigate the role of nitric oxide (NO) in the pathogenesis of early endometriosis-associated infertility. METHODS: The volume of peritoneal fluids was recorded and the concentration of NO in peritoneal fluid and serum was measured with a fluorescence method using 4, 5-diaminofluorescein (DAF-2) as an indicator, in 60 patients with early endometriosis-associated infertility (endometriosis group), 60 patients with tubal infertility (tubal infertility group) and 20 patients without infertility (control group). The IVF-ET outcomes between patients with endometriosis and tubal infertility were compared. RESULT: The volume of peritoneal fluids from endometriosis group patients increased significantly compared with that in tubal infertility group patients and control groups. The concentration of NO in peritoneal fluid of the control group,the tubal infertility group and the endometriosis group was 9.98, 13.76 and 20.72, respectively (P<0.017). Furthermore the concentration of NO in serum of the patients of control group,tubal infertility group and endometriosis group was 12.25, 13.00, 13.60, respectively; there were no significant differences among these three groups. There were no significant differences in implantation rate, pregnancy rate and abortion rate of IVF-ET between endometriosis group patients and tubal infertility group patients. However, the fertilization rate was significantly lower in endometriosis group patients than that in tubal infertility group patients. CONCLUSION: Changes of nitric oxide in peritoneal fluids may play an important role in the pathogenesis of early endometriosis-associated infertility and IVF-ET may serve as an alternative method for this type of infertility. SN - 1008-9292 UR - https://www.unboundmedicine.com/medline/citation/17924457/[Increased_nitric_oxide_levels_in_peritoneal_fluids_of_minor_endometriosis_patients_and_its_relation_to_IVF_ET_outcomes]_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -