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Stratification and symptom characteristics of non-erosive reflux disease based on acid and duodenogastroesophageal reflux.
J Gastroenterol Hepatol. 2008 Feb; 23(2):290-5.JG

Abstract

BACKGROUND AND AIM

The subgroups and symptom characteristics of non-erosive reflux disease (NERD) based on acid and duodenogastroesophageal reflux may be different in Chinese patients to Western patients. This study aimed to explore the stratification and symptom characteristics of patients with NERD.

METHODS

Patients with typical heartburn and/or acid regurgitation symptoms were enrolled. Each patient filled out a questionnaire. An upper gastrointestinal endoscopy was performed for each patient followed by simultaneous ambulatory 24-h esophageal pH and Bilitec (bilirubin) monitoring. A symptom index (SI) of > or =50% was considered to be positive.

RESULTS

Eighty-two consecutive NERD patients were evaluated. Abnormal (NERD pH+) and normal (NERD pH-) 24-h pH tests were found in 24 (29.3%) and 58 (70.7%) patients, respectively. Among 42 NERD pH- patients who reported heartburn symptoms during monitoring, SI was positive in 19 (45.2%) patients (NE-SI+) and negative in 23 (54.8%) patients (NE-SI-). Pathological duodenogastroesophageal reflux (DGER) was found in 43 (52.4%) patients. No significant differences were noted regarding the prevalence of other upper gastrointestinal symptoms, except for acid regurgitation in NERD pH+ and NERD pH- groups. Additionally, no significant differences were seen in the prevalence of other symptoms, except for chest pain, in groups with pathological and normal DGER.

CONCLUSION

The proportion of NERD patients with pathological acid reflux was somewhat lower than that reported in Western countries. The role of DGER in NERD may be important. It is difficult to differentiate whether NERD patients have pathological acid or bile reflux according to symptoms.

Authors+Show Affiliations

Department of Gastroenterology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17924953

Citation

Xiong, Li-Shou, et al. "Stratification and Symptom Characteristics of Non-erosive Reflux Disease Based On Acid and Duodenogastroesophageal Reflux." Journal of Gastroenterology and Hepatology, vol. 23, no. 2, 2008, pp. 290-5.
Xiong LS, Chen MH, Lin JK, et al. Stratification and symptom characteristics of non-erosive reflux disease based on acid and duodenogastroesophageal reflux. J Gastroenterol Hepatol. 2008;23(2):290-5.
Xiong, L. S., Chen, M. H., Lin, J. K., & Hu, P. J. (2008). Stratification and symptom characteristics of non-erosive reflux disease based on acid and duodenogastroesophageal reflux. Journal of Gastroenterology and Hepatology, 23(2), 290-5.
Xiong LS, et al. Stratification and Symptom Characteristics of Non-erosive Reflux Disease Based On Acid and Duodenogastroesophageal Reflux. J Gastroenterol Hepatol. 2008;23(2):290-5. PubMed PMID: 17924953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stratification and symptom characteristics of non-erosive reflux disease based on acid and duodenogastroesophageal reflux. AU - Xiong,Li-Shou, AU - Chen,Min-Hu, AU - Lin,Jin-Kun, AU - Hu,Pin-Jin, Y1 - 2007/10/09/ PY - 2007/10/11/pubmed PY - 2008/4/4/medline PY - 2007/10/11/entrez SP - 290 EP - 5 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 23 IS - 2 N2 - BACKGROUND AND AIM: The subgroups and symptom characteristics of non-erosive reflux disease (NERD) based on acid and duodenogastroesophageal reflux may be different in Chinese patients to Western patients. This study aimed to explore the stratification and symptom characteristics of patients with NERD. METHODS: Patients with typical heartburn and/or acid regurgitation symptoms were enrolled. Each patient filled out a questionnaire. An upper gastrointestinal endoscopy was performed for each patient followed by simultaneous ambulatory 24-h esophageal pH and Bilitec (bilirubin) monitoring. A symptom index (SI) of > or =50% was considered to be positive. RESULTS: Eighty-two consecutive NERD patients were evaluated. Abnormal (NERD pH+) and normal (NERD pH-) 24-h pH tests were found in 24 (29.3%) and 58 (70.7%) patients, respectively. Among 42 NERD pH- patients who reported heartburn symptoms during monitoring, SI was positive in 19 (45.2%) patients (NE-SI+) and negative in 23 (54.8%) patients (NE-SI-). Pathological duodenogastroesophageal reflux (DGER) was found in 43 (52.4%) patients. No significant differences were noted regarding the prevalence of other upper gastrointestinal symptoms, except for acid regurgitation in NERD pH+ and NERD pH- groups. Additionally, no significant differences were seen in the prevalence of other symptoms, except for chest pain, in groups with pathological and normal DGER. CONCLUSION: The proportion of NERD patients with pathological acid reflux was somewhat lower than that reported in Western countries. The role of DGER in NERD may be important. It is difficult to differentiate whether NERD patients have pathological acid or bile reflux according to symptoms. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/17924953/Stratification_and_symptom_characteristics_of_non_erosive_reflux_disease_based_on_acid_and_duodenogastroesophageal_reflux_ L2 - https://doi.org/10.1111/j.1440-1746.2007.05152.x DB - PRIME DP - Unbound Medicine ER -