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Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment.
Funct Neurol 2007 Jul-Sep; 22(3):133-6FN

Abstract

Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with a series of destabilising events within the brain that trigger cortical spreading depression (CSD). CSD can cause both migraine aura and trigeminal activation which, in turn, promotes neuropeptide release and triggers peripheral and central mechanisms that promote headache and autonomic activation. Susceptibility to CSD and to migraine is, in part, genetically determined. The best evidence to date comes from certain subtypes of migraine with aura in which point mutations in genes controlling translocation of calcium, sodium and potassium have been implicated. This review briefly summarises recent migraine research that supports CSD as an upstream driver of the migraine attack as well as an activator of the trigemino-vascular system.

Authors+Show Affiliations

Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. moskowitz@helix.mgh.harvard.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17925161

Citation

Moskowitz, Michael A.. "Genes, Proteases, Cortical Spreading Depression and Migraine: Impact On Pathophysiology and Treatment." Functional Neurology, vol. 22, no. 3, 2007, pp. 133-6.
Moskowitz MA. Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Funct Neurol. 2007;22(3):133-6.
Moskowitz, M. A. (2007). Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Functional Neurology, 22(3), pp. 133-6.
Moskowitz MA. Genes, Proteases, Cortical Spreading Depression and Migraine: Impact On Pathophysiology and Treatment. Funct Neurol. 2007;22(3):133-6. PubMed PMID: 17925161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. A1 - Moskowitz,Michael A, PY - 2007/10/11/pubmed PY - 2007/12/6/medline PY - 2007/10/11/entrez SP - 133 EP - 6 JF - Functional neurology JO - Funct. Neurol. VL - 22 IS - 3 N2 - Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with a series of destabilising events within the brain that trigger cortical spreading depression (CSD). CSD can cause both migraine aura and trigeminal activation which, in turn, promotes neuropeptide release and triggers peripheral and central mechanisms that promote headache and autonomic activation. Susceptibility to CSD and to migraine is, in part, genetically determined. The best evidence to date comes from certain subtypes of migraine with aura in which point mutations in genes controlling translocation of calcium, sodium and potassium have been implicated. This review briefly summarises recent migraine research that supports CSD as an upstream driver of the migraine attack as well as an activator of the trigemino-vascular system. SN - 0393-5264 UR - https://www.unboundmedicine.com/medline/citation/17925161/Genes_proteases_cortical_spreading_depression_and_migraine:_impact_on_pathophysiology_and_treatment_ L2 - http://www.functionalneurology.com/index.php?PAGE=article&ID=2383 DB - PRIME DP - Unbound Medicine ER -