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Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study.

Abstract

High intakes of calcium and dairy products have been suggested to be related to prostate cancer risk. Such associations were examined in the Multiethnic Cohort Study (1993-2002) among 82,483 men who completed a detailed quantitative food frequency questionnaire. During a mean follow-up of 8 years, 4,404 total cases of prostate cancer were identified. In Cox proportional hazards models, no association was found between calcium and vitamin D intake and total, advanced, or high-grade prostate cancer risk, whether for total intake, intake from foods, or intake from supplements, among all male participants or among nonusers of supplemental calcium. No association of calcium or vitamin D intake was seen across racial/ethnic groups. In analyses of food groups, dairy product and total milk consumption were not associated with prostate cancer risk. However, low-/nonfat milk was related to an increased risk and whole milk to a decreased risk of total prostate cancer; after stratification, these effects were limited to localized or low-grade tumors. Although the findings from this study do not support an association between the intakes of calcium and vitamin D and prostate cancer risk, they do suggest that an association with milk consumption may vary by fat content, particularly for early forms of this cancer.

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  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA. spark@crch.hawaii.edu

    , , , ,

    Source

    American journal of epidemiology 166:11 2007 Dec 01 pg 1259-69

    MeSH

    Aged
    Calcium, Dietary
    Cohort Studies
    Dairy Products
    Humans
    Likelihood Functions
    Male
    Middle Aged
    Prevalence
    Proportional Hazards Models
    Prostatic Neoplasms
    Registries
    Risk Factors
    SEER Program
    Surveys and Questionnaires
    United States
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17925283

    Citation

    Park, Song-Yi, et al. "Calcium, Vitamin D, and Dairy Product Intake and Prostate Cancer Risk: the Multiethnic Cohort Study." American Journal of Epidemiology, vol. 166, no. 11, 2007, pp. 1259-69.
    Park SY, Murphy SP, Wilkens LR, et al. Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study. Am J Epidemiol. 2007;166(11):1259-69.
    Park, S. Y., Murphy, S. P., Wilkens, L. R., Stram, D. O., Henderson, B. E., & Kolonel, L. N. (2007). Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study. American Journal of Epidemiology, 166(11), pp. 1259-69.
    Park SY, et al. Calcium, Vitamin D, and Dairy Product Intake and Prostate Cancer Risk: the Multiethnic Cohort Study. Am J Epidemiol. 2007 Dec 1;166(11):1259-69. PubMed PMID: 17925283.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study. AU - Park,Song-Yi, AU - Murphy,Suzanne P, AU - Wilkens,Lynne R, AU - Stram,Daniel O, AU - Henderson,Brian E, AU - Kolonel,Laurence N, Y1 - 2007/10/08/ PY - 2007/10/11/pubmed PY - 2007/12/14/medline PY - 2007/10/11/entrez SP - 1259 EP - 69 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 11 N2 - High intakes of calcium and dairy products have been suggested to be related to prostate cancer risk. Such associations were examined in the Multiethnic Cohort Study (1993-2002) among 82,483 men who completed a detailed quantitative food frequency questionnaire. During a mean follow-up of 8 years, 4,404 total cases of prostate cancer were identified. In Cox proportional hazards models, no association was found between calcium and vitamin D intake and total, advanced, or high-grade prostate cancer risk, whether for total intake, intake from foods, or intake from supplements, among all male participants or among nonusers of supplemental calcium. No association of calcium or vitamin D intake was seen across racial/ethnic groups. In analyses of food groups, dairy product and total milk consumption were not associated with prostate cancer risk. However, low-/nonfat milk was related to an increased risk and whole milk to a decreased risk of total prostate cancer; after stratification, these effects were limited to localized or low-grade tumors. Although the findings from this study do not support an association between the intakes of calcium and vitamin D and prostate cancer risk, they do suggest that an association with milk consumption may vary by fat content, particularly for early forms of this cancer. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/17925283/Calcium_vitamin_D_and_dairy_product_intake_and_prostate_cancer_risk:_the_Multiethnic_Cohort_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm269 DB - PRIME DP - Unbound Medicine ER -