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HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation.
Antivir Ther 2007; 12(6):971-5AT

Abstract

OBJECTIVES

To determine if the expression of CD38 on CD8+ T-cells could be used as a marker of viral replication <50 copies/ml in peripheral blood.

METHODS

In a cross-sectional study of patients attending a single HIV clinic in London, an ultra-sensitive HIV RNA viral load assay, with a limit of detection of 3 copies/ml, was used to determine HIV-1 replication in plasma in 70 patients who had sustained viral suppression <50 copies/ml by bDNA assays. Immune activation using the expression of CD38 on CD8+ T-cells was also assessed in patients on antiretroviral therapy (ART) with sustained viral suppression, individuals with persistent low-level viraemia <400 copies/ml and subjects failing ART (viral load >400 copies/mi).

RESULTS

There was no significant difference in the percentage of CD8+CD38++ T-cells between patients with <50 copies or <3 copies/ml. Immune activation was significantly increased in patients with persistent low-level viraemia and in subjects failing ART. CD4+ T-cell counts in patients on long-term successful ART are inversely associated with CD8+ T-cell activation.

CONCLUSIONS

T-cell activation in patients on long-term successful ART is not due to residual low-level viral replication in the blood compartment of HIV-1. CD8+ T-cell activation in this patient group appears to be associated with poor CD4+ T-cell recovery.

Authors+Show Affiliations

Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17926652

Citation

Steel, Alan, et al. "HIV-1 Viral Replication Below 50 Copies/ml in Patients On Antiretroviral Therapy Is Not Associated With CD8+ T-cell Activation." Antiviral Therapy, vol. 12, no. 6, 2007, pp. 971-5.
Steel A, Cox AE, Shamji MH, et al. HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation. Antivir Ther (Lond). 2007;12(6):971-5.
Steel, A., Cox, A. E., Shamji, M. H., John, L., Nelson, M., Henderson, D. C., ... Kelleher, P. (2007). HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation. Antiviral Therapy, 12(6), pp. 971-5.
Steel A, et al. HIV-1 Viral Replication Below 50 Copies/ml in Patients On Antiretroviral Therapy Is Not Associated With CD8+ T-cell Activation. Antivir Ther (Lond). 2007;12(6):971-5. PubMed PMID: 17926652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation. AU - Steel,Alan, AU - Cox,Alison E, AU - Shamji,Mohamed H, AU - John,Laurence, AU - Nelson,Mark, AU - Henderson,Don C, AU - Gotch,Frances M, AU - Gazzard,Brian G, AU - Kelleher,Peter, PY - 2007/10/12/pubmed PY - 2007/12/7/medline PY - 2007/10/12/entrez SP - 971 EP - 5 JF - Antiviral therapy JO - Antivir. Ther. (Lond.) VL - 12 IS - 6 N2 - OBJECTIVES: To determine if the expression of CD38 on CD8+ T-cells could be used as a marker of viral replication <50 copies/ml in peripheral blood. METHODS: In a cross-sectional study of patients attending a single HIV clinic in London, an ultra-sensitive HIV RNA viral load assay, with a limit of detection of 3 copies/ml, was used to determine HIV-1 replication in plasma in 70 patients who had sustained viral suppression <50 copies/ml by bDNA assays. Immune activation using the expression of CD38 on CD8+ T-cells was also assessed in patients on antiretroviral therapy (ART) with sustained viral suppression, individuals with persistent low-level viraemia <400 copies/ml and subjects failing ART (viral load >400 copies/mi). RESULTS: There was no significant difference in the percentage of CD8+CD38++ T-cells between patients with <50 copies or <3 copies/ml. Immune activation was significantly increased in patients with persistent low-level viraemia and in subjects failing ART. CD4+ T-cell counts in patients on long-term successful ART are inversely associated with CD8+ T-cell activation. CONCLUSIONS: T-cell activation in patients on long-term successful ART is not due to residual low-level viral replication in the blood compartment of HIV-1. CD8+ T-cell activation in this patient group appears to be associated with poor CD4+ T-cell recovery. SN - 1359-6535 UR - https://www.unboundmedicine.com/medline/citation/17926652/HIV_1_viral_replication_below_50_copies/ml_in_patients_on_antiretroviral_therapy_is_not_associated_with_CD8+_T_cell_activation_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -