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Saponins from the roots of Nylandtia spinosa.
J Nat Prod. 2007 Oct; 70(10):1680-2.JN

Abstract

From the roots of Nylandtia spinosa, four new triterpene saponins, 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-[beta- d-apiofuranosyl-(1-->3)]-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (1), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (2), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->4)-[beta- d-galactopyranosyl-(1-->2)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (3), and 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->3)-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (4), were isolated, together with the known tenuifolin. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1- 4 were evaluated for cytotoxicity against HCT 116 and HT-29 human colon cancer cells, but were inactive (IC50 > 5 microg/mL).

Authors+Show Affiliations

Laboratoire de Pharmacognosie, UMIB, UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7, Boulevard Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17927264

Citation

Diome, Cheikh, et al. "Saponins From the Roots of Nylandtia Spinosa." Journal of Natural Products, vol. 70, no. 10, 2007, pp. 1680-2.
Diome C, Mitaine-Offer AC, Miyamoto T, et al. Saponins from the roots of Nylandtia spinosa. J Nat Prod. 2007;70(10):1680-2.
Diome, C., Mitaine-Offer, A. C., Miyamoto, T., Delaude, C., Mirjolet, J. F., Duchamp, O., & Lacaille-Dubois, M. A. (2007). Saponins from the roots of Nylandtia spinosa. Journal of Natural Products, 70(10), 1680-2.
Diome C, et al. Saponins From the Roots of Nylandtia Spinosa. J Nat Prod. 2007;70(10):1680-2. PubMed PMID: 17927264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Saponins from the roots of Nylandtia spinosa. AU - Diome,Cheikh, AU - Mitaine-Offer,Anne-Claire, AU - Miyamoto,Tomofumi, AU - Delaude,Clément, AU - Mirjolet,Jean-François, AU - Duchamp,Olivier, AU - Lacaille-Dubois,Marie-Aleth, Y1 - 2007/10/11/ PY - 2007/10/12/pubmed PY - 2007/12/18/medline PY - 2007/10/12/entrez SP - 1680 EP - 2 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 10 N2 - From the roots of Nylandtia spinosa, four new triterpene saponins, 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-[beta- d-apiofuranosyl-(1-->3)]-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (1), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (2), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->4)-[beta- d-galactopyranosyl-(1-->2)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (3), and 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->3)-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester (4), were isolated, together with the known tenuifolin. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1- 4 were evaluated for cytotoxicity against HCT 116 and HT-29 human colon cancer cells, but were inactive (IC50 > 5 microg/mL). SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17927264/Saponins_from_the_roots_of_Nylandtia_spinosa_ L2 - https://doi.org/10.1021/np0703186 DB - PRIME DP - Unbound Medicine ER -