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Plasma carotenoids and prostate cancer: a population-based case-control study in Arkansas.

Abstract

Carotenoids possess antioxidant properties and thus may protect against prostate cancer. Epidemiological studies of dietary carotenoids and this malignancy were inconsistent, partially due to dietary assessment error. In this study, we aimed to investigate the relation between plasma concentrations of carotenoids and the risk of prostate cancer in a population-based case-control study in Arkansas. Cases (n = 193) were men with prostate cancer diagnosed in 3 major hospitals, and controls (n = 197) were matched to cases by age, race, and county of residence. After adjustment for confounders, plasma levels of lycopene, lutein/zeaxanthin, and beta-cryptoxanthin were inversely associated with prostate cancer risk. Subjects in the highest quartile of plasma lycopene (513.7 microg/l) had a 55% lower risk of prostate cancer than those in the lowest quartile (140.5 microg/l; P trend = 0.042). No apparent association was observed for plasma alpha-carotene and beta-carotene. Further adjustment for the other 4 carotenoids did not materially alter the risk estimates for plasma lycopene, lutein/zeaxanthin, and beta-cryptoxanthin but appeared to result in an elevated risk with high levels of plasma alpha-carotene and beta-carotene. The results of all analyses did not vary substantially by age, race, and smoking status. This study added to the emerging evidence that high circulating levels of lycopene, lutein/zeaxanthin, and beta-cryptoxanthin are associated with a low risk of prostate cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Fay W Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. zhangjianjun@uams.edu

    , , , , ,

    Source

    Nutrition and cancer 59:1 2007 pg 46-53

    MeSH

    Antioxidants
    Arkansas
    Carotenoids
    Case-Control Studies
    Cryptoxanthins
    Humans
    Lutein
    Lycopene
    Male
    Middle Aged
    Prostatic Neoplasms
    Risk Factors
    Xanthophylls
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    17927501

    Citation

    Zhang, Jianjun, et al. "Plasma Carotenoids and Prostate Cancer: a Population-based Case-control Study in Arkansas." Nutrition and Cancer, vol. 59, no. 1, 2007, pp. 46-53.
    Zhang J, Dhakal I, Stone A, et al. Plasma carotenoids and prostate cancer: a population-based case-control study in Arkansas. Nutr Cancer. 2007;59(1):46-53.
    Zhang, J., Dhakal, I., Stone, A., Ning, B., Greene, G., Lang, N. P., & Kadlubar, F. F. (2007). Plasma carotenoids and prostate cancer: a population-based case-control study in Arkansas. Nutrition and Cancer, 59(1), pp. 46-53.
    Zhang J, et al. Plasma Carotenoids and Prostate Cancer: a Population-based Case-control Study in Arkansas. Nutr Cancer. 2007;59(1):46-53. PubMed PMID: 17927501.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma carotenoids and prostate cancer: a population-based case-control study in Arkansas. AU - Zhang,Jianjun, AU - Dhakal,Ishwori, AU - Stone,Angie, AU - Ning,Baitang, AU - Greene,Graham, AU - Lang,Nicholas P, AU - Kadlubar,Fred F, PY - 2007/10/12/pubmed PY - 2008/1/29/medline PY - 2007/10/12/entrez SP - 46 EP - 53 JF - Nutrition and cancer JO - Nutr Cancer VL - 59 IS - 1 N2 - Carotenoids possess antioxidant properties and thus may protect against prostate cancer. Epidemiological studies of dietary carotenoids and this malignancy were inconsistent, partially due to dietary assessment error. In this study, we aimed to investigate the relation between plasma concentrations of carotenoids and the risk of prostate cancer in a population-based case-control study in Arkansas. Cases (n = 193) were men with prostate cancer diagnosed in 3 major hospitals, and controls (n = 197) were matched to cases by age, race, and county of residence. After adjustment for confounders, plasma levels of lycopene, lutein/zeaxanthin, and beta-cryptoxanthin were inversely associated with prostate cancer risk. Subjects in the highest quartile of plasma lycopene (513.7 microg/l) had a 55% lower risk of prostate cancer than those in the lowest quartile (140.5 microg/l; P trend = 0.042). No apparent association was observed for plasma alpha-carotene and beta-carotene. Further adjustment for the other 4 carotenoids did not materially alter the risk estimates for plasma lycopene, lutein/zeaxanthin, and beta-cryptoxanthin but appeared to result in an elevated risk with high levels of plasma alpha-carotene and beta-carotene. The results of all analyses did not vary substantially by age, race, and smoking status. This study added to the emerging evidence that high circulating levels of lycopene, lutein/zeaxanthin, and beta-cryptoxanthin are associated with a low risk of prostate cancer. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/17927501/Plasma_carotenoids_and_prostate_cancer:_a_population_based_case_control_study_in_Arkansas_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580701385900 DB - PRIME DP - Unbound Medicine ER -