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Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study.
Nutr Cancer. 2007; 59(1):54-61.NC

Abstract

Epidemiological studies and laboratory data suggest that vitamin D may protect against the development of cancer, including breast cancer. Vitamin D supply affects the bioavailability of dietary calcium, which might also have anticarcinogenic effects. However, few studies considered them jointly. We used a population-based case-control study in Germany to examine the independent and joint effects of dietary vitamin D and calcium on premenopausal breast cancer risk. Dietary information was assessed using a validated food frequency questionnaire from 278 premenopausal cases and 666 age-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariate models adjusting vitamin D models for calcium intake and vice versa. Breast cancer risk was significantly inversely associated with vitamin D intake. The OR and 95% CI for the highest intake category (> or = 5 microg/day) was 0.50 (95% CI = 0.26-0.96) compared with the lowest (< 2 microg/day; P(trend) = 0.02). Dietary calcium intake was not associated with breast cancer (OR = 0.73, 95% CI = 0.41-1.29) for the highest (> or = 1,300 mg/day) versus the lowest category (< 700 mg/day), P(trend) = 0.29). No statistically significant interaction between the 2 nutrients was observed. Our data support a protective effect of dietary vitamin D on premenopausal breast cancer risk independent of dietary calcium intake.

Authors+Show Affiliations

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17927502

Citation

Abbas, Sascha, et al. "Dietary Vitamin D and Calcium Intake and Premenopausal Breast Cancer Risk in a German Case-control Study." Nutrition and Cancer, vol. 59, no. 1, 2007, pp. 54-61.
Abbas S, Linseisen J, Chang-Claude J. Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study. Nutr Cancer. 2007;59(1):54-61.
Abbas, S., Linseisen, J., & Chang-Claude, J. (2007). Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study. Nutrition and Cancer, 59(1), 54-61.
Abbas S, Linseisen J, Chang-Claude J. Dietary Vitamin D and Calcium Intake and Premenopausal Breast Cancer Risk in a German Case-control Study. Nutr Cancer. 2007;59(1):54-61. PubMed PMID: 17927502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study. AU - Abbas,Sascha, AU - Linseisen,Jakob, AU - Chang-Claude,Jenny, PY - 2007/10/12/pubmed PY - 2008/1/29/medline PY - 2007/10/12/entrez SP - 54 EP - 61 JF - Nutrition and cancer JO - Nutr Cancer VL - 59 IS - 1 N2 - Epidemiological studies and laboratory data suggest that vitamin D may protect against the development of cancer, including breast cancer. Vitamin D supply affects the bioavailability of dietary calcium, which might also have anticarcinogenic effects. However, few studies considered them jointly. We used a population-based case-control study in Germany to examine the independent and joint effects of dietary vitamin D and calcium on premenopausal breast cancer risk. Dietary information was assessed using a validated food frequency questionnaire from 278 premenopausal cases and 666 age-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariate models adjusting vitamin D models for calcium intake and vice versa. Breast cancer risk was significantly inversely associated with vitamin D intake. The OR and 95% CI for the highest intake category (> or = 5 microg/day) was 0.50 (95% CI = 0.26-0.96) compared with the lowest (< 2 microg/day; P(trend) = 0.02). Dietary calcium intake was not associated with breast cancer (OR = 0.73, 95% CI = 0.41-1.29) for the highest (> or = 1,300 mg/day) versus the lowest category (< 700 mg/day), P(trend) = 0.29). No statistically significant interaction between the 2 nutrients was observed. Our data support a protective effect of dietary vitamin D on premenopausal breast cancer risk independent of dietary calcium intake. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/17927502/Dietary_vitamin_D_and_calcium_intake_and_premenopausal_breast_cancer_risk_in_a_German_case_control_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580701390223 DB - PRIME DP - Unbound Medicine ER -