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Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy.
Exp Dermatol. 2007 Nov; 16(11):891-8.ED

Abstract

To study the mode of action of moisturizers on human skin, hydrophilic moisturizers in water and neat lipophilic moisturizers were applied on excised skin for 24 h at 32 degrees C. Samples of the treated skin were subsequently visualized in a cryoscanning electron microscope. The stratum corneum (SC) appeared as a region of swollen corneocytes (the swollen region) sandwiched between two layers of relatively dry corneocytes (the upper and lower non-swelling regions respectively). Lipophilic moisturizers increased the water content of the SC, whereas hydrophilic moisturizers can also reduce the water content of the SC. When focusing on the effect of the moisturizers on the three different regions, it was observed that cells in the swelling region are most sensitive to the application of the moisturizers and that the change in SC thickness is most influenced by the change in the thickness of the swelling region. Summarizing, SC cells are not equally sensitive to moisturizer application: centrally located corneocytes are more sensitive than corneocytes in the upper and the lowest regions of the SC.

Authors+Show Affiliations

Gorlaeus Laboratories, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17927571

Citation

Caussin, Julia, et al. "Lipophilic and Hydrophilic Moisturizers Show Different Actions On Human Skin as Revealed By Cryo Scanning Electron Microscopy." Experimental Dermatology, vol. 16, no. 11, 2007, pp. 891-8.
Caussin J, Groenink HW, de Graaff AM, et al. Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy. Exp Dermatol. 2007;16(11):891-8.
Caussin, J., Groenink, H. W., de Graaff, A. M., Gooris, G. S., Wiechers, J. W., van Aelst, A. C., & Bouwstra, J. A. (2007). Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy. Experimental Dermatology, 16(11), 891-8.
Caussin J, et al. Lipophilic and Hydrophilic Moisturizers Show Different Actions On Human Skin as Revealed By Cryo Scanning Electron Microscopy. Exp Dermatol. 2007;16(11):891-8. PubMed PMID: 17927571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy. AU - Caussin,Julia, AU - Groenink,H W Wouter, AU - de Graaff,Anko M, AU - Gooris,Gert S, AU - Wiechers,Johann W, AU - van Aelst,Adriaan C, AU - Bouwstra,Joke A, PY - 2007/10/12/pubmed PY - 2008/1/8/medline PY - 2007/10/12/entrez SP - 891 EP - 8 JF - Experimental dermatology JO - Exp Dermatol VL - 16 IS - 11 N2 - To study the mode of action of moisturizers on human skin, hydrophilic moisturizers in water and neat lipophilic moisturizers were applied on excised skin for 24 h at 32 degrees C. Samples of the treated skin were subsequently visualized in a cryoscanning electron microscope. The stratum corneum (SC) appeared as a region of swollen corneocytes (the swollen region) sandwiched between two layers of relatively dry corneocytes (the upper and lower non-swelling regions respectively). Lipophilic moisturizers increased the water content of the SC, whereas hydrophilic moisturizers can also reduce the water content of the SC. When focusing on the effect of the moisturizers on the three different regions, it was observed that cells in the swelling region are most sensitive to the application of the moisturizers and that the change in SC thickness is most influenced by the change in the thickness of the swelling region. Summarizing, SC cells are not equally sensitive to moisturizer application: centrally located corneocytes are more sensitive than corneocytes in the upper and the lowest regions of the SC. SN - 0906-6705 UR - https://www.unboundmedicine.com/medline/citation/17927571/Lipophilic_and_hydrophilic_moisturizers_show_different_actions_on_human_skin_as_revealed_by_cryo_scanning_electron_microscopy_ L2 - https://doi.org/10.1111/j.1600-0625.2007.00596.x DB - PRIME DP - Unbound Medicine ER -