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[Cytokine responses after lobectomy: a prospective randomized comparison of video-assisted thoracoscopic surgery and minimal incision thoracotomy].
Ai Zheng. 2007 Sep; 26(9):991-5.AZ

Abstract

BACKGROUND & OBJECTIVE

The cytokine network plays a pivotal role in inducing acute-phase inflammatory and immunologic responses to surgical trauma. Whether lesser release of cytokines by mini-invasive operation can reduce acute-phase responses and better preserve immune functions needs to be explored. This prospective randomized study was to compare the effects of video-assisted thoracoscopic surgery (VATS) and minimal incision thoracotomy (MIT) on serum levels of cytokines after lobectomy for clinical early stage non-small cell lung cancer (NSCLC).

METHODS

From Mar. 2004 to Dec. 2006, 47 consecutive patients with early stage NSCLC (tumor size was <or=6 cm as showed on CT scan) were recruited and randomized into VATS group (n=24) and MIT group (n=23). Two patients in VATS group were excluded for conversion to posterolateral thoracotomy because of uncontrolled bleeding and dense pleural adhesion; 1 in MIT group was excluded for intraoperative blood transfusion. Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-2, IL-4, IL-6, and IL-10 were measured by cytometric bead array (CBA) before operation and at 4, 24, and 48 h after operation.

RESULTS

The serum levels of TNF-alpha, IL-2 and IL-4 were low after operation in both groups, and there were no significant differences between the 2 groups. Both IL-6 and IL-10 reached peak serum concentration (C max) at 4 h after operation: the C max of IL-6 was (91.0+/-63.9) ng/L in VATS group and (84.2+/-53.1) ng/L in MIT group (P=0.732)슩 the C max of IL-10 was (12.6+/-8.1) ng/L in VATS group and (16.3+/-11.2) ng/L in MIT group (P=0.235). The changes in serum concentration of IL-6 and IL-10 in the 2 groups among the 4 time points were not significant (F=0.143, P=0.708 for IL-6; F=0.000, P=0.996 for IL-10).

CONCLUSIONS

Compared with MIT, VATS major lung resection can't reduce postoperative release of cytokines. The clinical significance of these findings remains to be fully elucidated.

Authors+Show Affiliations

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China. drlongh@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17927859

Citation

Long, Hao, et al. "[Cytokine Responses After Lobectomy: a Prospective Randomized Comparison of Video-assisted Thoracoscopic Surgery and Minimal Incision Thoracotomy]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 26, no. 9, 2007, pp. 991-5.
Long H, Lin ZC, Situ DR, et al. [Cytokine responses after lobectomy: a prospective randomized comparison of video-assisted thoracoscopic surgery and minimal incision thoracotomy]. Ai Zheng. 2007;26(9):991-5.
Long, H., Lin, Z. C., Situ, D. R., He, L. R., Yan, S. L., Lin, Y. B., & Rong, T. H. (2007). [Cytokine responses after lobectomy: a prospective randomized comparison of video-assisted thoracoscopic surgery and minimal incision thoracotomy]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 26(9), 991-5.
Long H, et al. [Cytokine Responses After Lobectomy: a Prospective Randomized Comparison of Video-assisted Thoracoscopic Surgery and Minimal Incision Thoracotomy]. Ai Zheng. 2007;26(9):991-5. PubMed PMID: 17927859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cytokine responses after lobectomy: a prospective randomized comparison of video-assisted thoracoscopic surgery and minimal incision thoracotomy]. AU - Long,Hao, AU - Lin,Zhi-Chao, AU - Situ,Dong-Rong, AU - He,Li-Rong, AU - Yan,Su-Li, AU - Lin,Yong-Bin, AU - Rong,Tie-Hua, PY - 2007/10/12/pubmed PY - 2009/12/16/medline PY - 2007/10/12/entrez SP - 991 EP - 5 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 26 IS - 9 N2 - BACKGROUND & OBJECTIVE: The cytokine network plays a pivotal role in inducing acute-phase inflammatory and immunologic responses to surgical trauma. Whether lesser release of cytokines by mini-invasive operation can reduce acute-phase responses and better preserve immune functions needs to be explored. This prospective randomized study was to compare the effects of video-assisted thoracoscopic surgery (VATS) and minimal incision thoracotomy (MIT) on serum levels of cytokines after lobectomy for clinical early stage non-small cell lung cancer (NSCLC). METHODS: From Mar. 2004 to Dec. 2006, 47 consecutive patients with early stage NSCLC (tumor size was <or=6 cm as showed on CT scan) were recruited and randomized into VATS group (n=24) and MIT group (n=23). Two patients in VATS group were excluded for conversion to posterolateral thoracotomy because of uncontrolled bleeding and dense pleural adhesion; 1 in MIT group was excluded for intraoperative blood transfusion. Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-2, IL-4, IL-6, and IL-10 were measured by cytometric bead array (CBA) before operation and at 4, 24, and 48 h after operation. RESULTS: The serum levels of TNF-alpha, IL-2 and IL-4 were low after operation in both groups, and there were no significant differences between the 2 groups. Both IL-6 and IL-10 reached peak serum concentration (C max) at 4 h after operation: the C max of IL-6 was (91.0+/-63.9) ng/L in VATS group and (84.2+/-53.1) ng/L in MIT group (P=0.732)슩 the C max of IL-10 was (12.6+/-8.1) ng/L in VATS group and (16.3+/-11.2) ng/L in MIT group (P=0.235). The changes in serum concentration of IL-6 and IL-10 in the 2 groups among the 4 time points were not significant (F=0.143, P=0.708 for IL-6; F=0.000, P=0.996 for IL-10). CONCLUSIONS: Compared with MIT, VATS major lung resection can't reduce postoperative release of cytokines. The clinical significance of these findings remains to be fully elucidated. UR - https://www.unboundmedicine.com/medline/citation/17927859/[Cytokine_responses_after_lobectomy:_a_prospective_randomized_comparison_of_video_assisted_thoracoscopic_surgery_and_minimal_incision_thoracotomy]_ L2 - http://www.cancercommun.com/fulltextnew.asp?y=2007&amp;m=9&amp;ym=991 DB - PRIME DP - Unbound Medicine ER -