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Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study.
Pain 2008; 137(1):147-55PAIN

Abstract

Irritable bowel syndrome (IBS) affects up to 22% of the general population. Its aetiology remains unclear. Previously reported cross-sectional associations with psychological distress and depression are not fully understood. We hypothesised that psychosocial factors, particularly those associated with somatisation, would act as risk markers for the onset of IBS. We conducted a community-based prospective study of subjects, aged 25-65 years, randomly selected from the registers of three primary care practices. Responses to a detailed questionnaire allowed subjects' IBS status to be classified using a modified version of the Rome II criteria. The questionnaire also included validated psychosocial instruments. Subjects free of IBS at baseline and eligible for follow-up 15 months later formed the cohort for this analysis (n=3732). An adjusted participation rate of 71% (n=2456) was achieved at follow-up. 3.5% (n=86) of subjects developed IBS. After adjustment for age, gender and baseline abdominal pain status, high levels of illness behaviour (odds ratio (OR)=5.2; 95% confidence interval (95% CI) 2.5-11.0), anxiety (OR=2.0; 95% CI 0.98-4.1), sleep problems (OR=1.6; 95% CI 0.8-3.2), and somatic symptoms (OR=1.6; 95% CI 0.8-2.9) were found to be independent predictors of IBS onset. This study has demonstrated that psychosocial factors indicative of the process of somatisation are independent risk markers for the development of IBS in a group of subjects previously free of IBS. Similar relationships are observed in other "functional" disorders, further supporting the hypothesis that they have similar aetiologies.

Authors+Show Affiliations

Arthritis Research Campaign (ARC) Epidemiology Unit, School of Translational Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17928145

Citation

Nicholl, B I., et al. "Psychosocial Risk Markers for New Onset Irritable Bowel Syndrome--results of a Large Prospective Population-based Study." Pain, vol. 137, no. 1, 2008, pp. 147-55.
Nicholl BI, Halder SL, Macfarlane GJ, et al. Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study. Pain. 2008;137(1):147-55.
Nicholl, B. I., Halder, S. L., Macfarlane, G. J., Thompson, D. G., O'Brien, S., Musleh, M., & McBeth, J. (2008). Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study. Pain, 137(1), pp. 147-55.
Nicholl BI, et al. Psychosocial Risk Markers for New Onset Irritable Bowel Syndrome--results of a Large Prospective Population-based Study. Pain. 2008;137(1):147-55. PubMed PMID: 17928145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study. AU - Nicholl,B I, AU - Halder,S L, AU - Macfarlane,G J, AU - Thompson,D G, AU - O'Brien,S, AU - Musleh,M, AU - McBeth,J, Y1 - 2007/10/10/ PY - 2007/03/22/received PY - 2007/08/14/revised PY - 2007/08/21/accepted PY - 2007/10/12/pubmed PY - 2008/12/17/medline PY - 2007/10/12/entrez SP - 147 EP - 55 JF - Pain JO - Pain VL - 137 IS - 1 N2 - Irritable bowel syndrome (IBS) affects up to 22% of the general population. Its aetiology remains unclear. Previously reported cross-sectional associations with psychological distress and depression are not fully understood. We hypothesised that psychosocial factors, particularly those associated with somatisation, would act as risk markers for the onset of IBS. We conducted a community-based prospective study of subjects, aged 25-65 years, randomly selected from the registers of three primary care practices. Responses to a detailed questionnaire allowed subjects' IBS status to be classified using a modified version of the Rome II criteria. The questionnaire also included validated psychosocial instruments. Subjects free of IBS at baseline and eligible for follow-up 15 months later formed the cohort for this analysis (n=3732). An adjusted participation rate of 71% (n=2456) was achieved at follow-up. 3.5% (n=86) of subjects developed IBS. After adjustment for age, gender and baseline abdominal pain status, high levels of illness behaviour (odds ratio (OR)=5.2; 95% confidence interval (95% CI) 2.5-11.0), anxiety (OR=2.0; 95% CI 0.98-4.1), sleep problems (OR=1.6; 95% CI 0.8-3.2), and somatic symptoms (OR=1.6; 95% CI 0.8-2.9) were found to be independent predictors of IBS onset. This study has demonstrated that psychosocial factors indicative of the process of somatisation are independent risk markers for the development of IBS in a group of subjects previously free of IBS. Similar relationships are observed in other "functional" disorders, further supporting the hypothesis that they have similar aetiologies. SN - 1872-6623 UR - https://www.unboundmedicine.com/medline/citation/17928145/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(07)00465-4 DB - PRIME DP - Unbound Medicine ER -