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MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations.
Expert Rev Vaccines. 2007 Oct; 6(5):659-65.ER

Abstract

Influenza is a highly contagious respiratory disease associated with substantial morbidity and mortality in vulnerable populations, especially the elderly. Influenza viruses are unique in that they undergo small mutations and antigenic variation in their hemagglutinin and neuraminidase genes. Owing to the senescence of the immune system, the ability to mount novel immune responses may be particularly compromised in older people. Fluad (Novartis Vaccines), an MF59-adjuvanted subunit influenza vaccine, was formulated in order to achieve greater immunogenicity in those groups who need a higher protection than that brought about by conventional vaccines. This article summarizes the main characteristics of MF59-adjuvanted subunit influenza vaccine, the clinical effectiveness data that have been generated in recent years and future developments.

Authors+Show Affiliations

Centre de Salut Pública de Castelló, Avda del Mar, 12, E 12100, Castelló, Spain. jpuigb@terra.esNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17931147

Citation

Puig Barberà, Joan, and David González Vidal. "MF59-adjuvanted Subunit Influenza Vaccine: an Improved Interpandemic Influenza Vaccine for Vulnerable Populations." Expert Review of Vaccines, vol. 6, no. 5, 2007, pp. 659-65.
Puig Barberà J, González Vidal D. MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations. Expert Rev Vaccines. 2007;6(5):659-65.
Puig Barberà, J., & González Vidal, D. (2007). MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations. Expert Review of Vaccines, 6(5), 659-65.
Puig Barberà J, González Vidal D. MF59-adjuvanted Subunit Influenza Vaccine: an Improved Interpandemic Influenza Vaccine for Vulnerable Populations. Expert Rev Vaccines. 2007;6(5):659-65. PubMed PMID: 17931147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations. AU - Puig Barberà,Joan, AU - González Vidal,David, PY - 2007/10/13/pubmed PY - 2007/12/6/medline PY - 2007/10/13/entrez SP - 659 EP - 65 JF - Expert review of vaccines JO - Expert Rev Vaccines VL - 6 IS - 5 N2 - Influenza is a highly contagious respiratory disease associated with substantial morbidity and mortality in vulnerable populations, especially the elderly. Influenza viruses are unique in that they undergo small mutations and antigenic variation in their hemagglutinin and neuraminidase genes. Owing to the senescence of the immune system, the ability to mount novel immune responses may be particularly compromised in older people. Fluad (Novartis Vaccines), an MF59-adjuvanted subunit influenza vaccine, was formulated in order to achieve greater immunogenicity in those groups who need a higher protection than that brought about by conventional vaccines. This article summarizes the main characteristics of MF59-adjuvanted subunit influenza vaccine, the clinical effectiveness data that have been generated in recent years and future developments. SN - 1744-8395 UR - https://www.unboundmedicine.com/medline/citation/17931147/MF59_adjuvanted_subunit_influenza_vaccine:_an_improved_interpandemic_influenza_vaccine_for_vulnerable_populations_ L2 - https://www.tandfonline.com/doi/full/10.1586/14760584.6.5.659 DB - PRIME DP - Unbound Medicine ER -