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Liver cancer and hepatitis B and C in New South Wales, 1990-2002: a linkage study.
Aust N Z J Public Health. 2007 Oct; 31(5):475-82.AN

Abstract

BACKGROUND/AIMS

Hepatocellular carcinoma (HCC) incidence has increased in Australia in the past 20-30 years. We conducted a community-based linkage study to examine the characteristics of hepatocellular carcinoma with particular reference to hepatitis B and C infections.

METHODS

Hepatocellular carcinoma cases (n=2,072) notified to the New South Wales (NSW) Central Cancer Registry from 1990 to 2002 were probabilistically linked to HBV and HCV diagnoses notified to NSW Health. Sex, age, year of diagnosis, region of birth, method of diagnosis and spread at diagnosis and survival were compared by linkage group.

RESULTS

Hepatocellular carcinoma incidence increased from 1.4/100,000 in 1990 to 2.8/100,000 in 2002. Incidence varied by region of birth (p<0.001), with people born in Vietnam having the highest relative rate compared with those born in Australia (RR=11.7, 95% CI 9.8-13.8). Of the hepatocellular carcinoma records, 15.6%, 12.9% and 0.8% were linked to hepatitis B, hepatitis C and hepatitis B/C co-infection respectively and 70.7% were unlinked. Median age at diagnosis of HCV-related hepatocellular carcinoma varied markedly at 51, 68 and 71 years for Australian, European, and Asian-born groups, respectively (p<0.0001).

CONCLUSION

Contrasting age distribution of HCV-related HCC by country/region of birth is consistent with divergent patterns of HCV transmission.

IMPLICATIONS

These data highlight the increase in HCC in NSW and the divergent populations whose needs in terms of treatment, care and prevention will need to be met.

Authors+Show Affiliations

National Centre in HIV Epidemiology and Clinical Research, University of New South Wales. jamin@nchecr.unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17931297

Citation

Amin, Janaki, et al. "Liver Cancer and Hepatitis B and C in New South Wales, 1990-2002: a Linkage Study." Australian and New Zealand Journal of Public Health, vol. 31, no. 5, 2007, pp. 475-82.
Amin J, O'Connell D, Bartlett M, et al. Liver cancer and hepatitis B and C in New South Wales, 1990-2002: a linkage study. Aust N Z J Public Health. 2007;31(5):475-82.
Amin, J., O'Connell, D., Bartlett, M., Tracey, E., Kaldor, J., Law, M., & Dore, G. (2007). Liver cancer and hepatitis B and C in New South Wales, 1990-2002: a linkage study. Australian and New Zealand Journal of Public Health, 31(5), 475-82.
Amin J, et al. Liver Cancer and Hepatitis B and C in New South Wales, 1990-2002: a Linkage Study. Aust N Z J Public Health. 2007;31(5):475-82. PubMed PMID: 17931297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver cancer and hepatitis B and C in New South Wales, 1990-2002: a linkage study. AU - Amin,Janaki, AU - O'Connell,Dianne, AU - Bartlett,Mark, AU - Tracey,Elizabeth, AU - Kaldor,John, AU - Law,Matthew, AU - Dore,Gregory, PY - 2007/10/13/pubmed PY - 2008/1/5/medline PY - 2007/10/13/entrez SP - 475 EP - 82 JF - Australian and New Zealand journal of public health JO - Aust N Z J Public Health VL - 31 IS - 5 N2 - BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) incidence has increased in Australia in the past 20-30 years. We conducted a community-based linkage study to examine the characteristics of hepatocellular carcinoma with particular reference to hepatitis B and C infections. METHODS: Hepatocellular carcinoma cases (n=2,072) notified to the New South Wales (NSW) Central Cancer Registry from 1990 to 2002 were probabilistically linked to HBV and HCV diagnoses notified to NSW Health. Sex, age, year of diagnosis, region of birth, method of diagnosis and spread at diagnosis and survival were compared by linkage group. RESULTS: Hepatocellular carcinoma incidence increased from 1.4/100,000 in 1990 to 2.8/100,000 in 2002. Incidence varied by region of birth (p<0.001), with people born in Vietnam having the highest relative rate compared with those born in Australia (RR=11.7, 95% CI 9.8-13.8). Of the hepatocellular carcinoma records, 15.6%, 12.9% and 0.8% were linked to hepatitis B, hepatitis C and hepatitis B/C co-infection respectively and 70.7% were unlinked. Median age at diagnosis of HCV-related hepatocellular carcinoma varied markedly at 51, 68 and 71 years for Australian, European, and Asian-born groups, respectively (p<0.0001). CONCLUSION: Contrasting age distribution of HCV-related HCC by country/region of birth is consistent with divergent patterns of HCV transmission. IMPLICATIONS: These data highlight the increase in HCC in NSW and the divergent populations whose needs in terms of treatment, care and prevention will need to be met. SN - 1326-0200 UR - https://www.unboundmedicine.com/medline/citation/17931297/Liver_cancer_and_hepatitis_B_and_C_in_New_South_Wales_1990_2002:_a_linkage_study_ DB - PRIME DP - Unbound Medicine ER -