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Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: a nested case-control design using incident cancer cases.

Abstract

Oral cancer is one of the most common cancers in the world, with two-thirds of the cases occurring in developing countries. While cohort and nested case-control study designs offer various methodological strengths, the role of tobacco and alcohol consumption in the etiology of oral cancer has been assessed mainly in case-control studies. The role of tobacco chewing, smoking and alcohol drinking patterns on the risk of cancer of the oral cavity was evaluated using a nested case-control design on data from a randomized control trial conducted between 1996 and 2004 in Trivandrum, India. Data from 282 incident oral cancer cases and 1410 matched controls were analyzed using multivariate conditional logistic regression models. Tobacco chewing was the strongest risk factor associated with oral cancer. The adjusted odds ratios (ORs) for chewers were 3.1 (95% confidence interval (CI)=2.1-4.6) for men and 11.0 (95%CI=5.8-20.7) for women. Effects of chewing pan with or without tobacco on oral cancer risk were elevated for both sexes. Bidi smoking increased the risk of oral cancer in men (OR=1.9, 95%CI=1.1-3.2). Dose-response relations were observed for the frequency and duration of chewing and alcohol drinking, as well as in duration of bidi smoking. Given the relatively poor survival rates of oral cancer patients, cessation of tobacco and moderation of alcohol use remain the key elements in oral cancer prevention and control.

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  • Authors+Show Affiliations

    ,

    Screening Group, Pathogenesis and Prevention Cluster, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. muwonger@students.iarc.fr <muwonger@students.iarc.fr>

    , , , , ,

    Source

    Oral oncology 44:5 2008 May pg 446-54

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Carcinoma, Squamous Cell
    Case-Control Studies
    Female
    Health Knowledge, Attitudes, Practice
    Humans
    Incidence
    India
    Male
    Middle Aged
    Mouth Neoplasms
    Precancerous Conditions
    Prognosis
    Risk Assessment
    Risk Factors
    Smoking
    Tobacco, Smokeless

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17933578

    Citation

    Muwonge, Richard, et al. "Role of Tobacco Smoking, Chewing and Alcohol Drinking in the Risk of Oral Cancer in Trivandrum, India: a Nested Case-control Design Using Incident Cancer Cases." Oral Oncology, vol. 44, no. 5, 2008, pp. 446-54.
    Muwonge R, Ramadas K, Sankila R, et al. Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: a nested case-control design using incident cancer cases. Oral Oncol. 2008;44(5):446-54.
    Muwonge, R., Ramadas, K., Sankila, R., Thara, S., Thomas, G., Vinoda, J., & Sankaranarayanan, R. (2008). Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: a nested case-control design using incident cancer cases. Oral Oncology, 44(5), pp. 446-54.
    Muwonge R, et al. Role of Tobacco Smoking, Chewing and Alcohol Drinking in the Risk of Oral Cancer in Trivandrum, India: a Nested Case-control Design Using Incident Cancer Cases. Oral Oncol. 2008;44(5):446-54. PubMed PMID: 17933578.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: a nested case-control design using incident cancer cases. AU - Muwonge,Richard, AU - Ramadas,Kunnambath, AU - Sankila,Risto, AU - Thara,Somanathan, AU - Thomas,Gigi, AU - Vinoda,Jissa, AU - Sankaranarayanan,Rengaswamy, Y1 - 2007/10/22/ PY - 2007/04/03/received PY - 2007/06/01/revised PY - 2007/06/05/accepted PY - 2007/10/16/pubmed PY - 2008/12/17/medline PY - 2007/10/16/entrez SP - 446 EP - 54 JF - Oral oncology JO - Oral Oncol. VL - 44 IS - 5 N2 - Oral cancer is one of the most common cancers in the world, with two-thirds of the cases occurring in developing countries. While cohort and nested case-control study designs offer various methodological strengths, the role of tobacco and alcohol consumption in the etiology of oral cancer has been assessed mainly in case-control studies. The role of tobacco chewing, smoking and alcohol drinking patterns on the risk of cancer of the oral cavity was evaluated using a nested case-control design on data from a randomized control trial conducted between 1996 and 2004 in Trivandrum, India. Data from 282 incident oral cancer cases and 1410 matched controls were analyzed using multivariate conditional logistic regression models. Tobacco chewing was the strongest risk factor associated with oral cancer. The adjusted odds ratios (ORs) for chewers were 3.1 (95% confidence interval (CI)=2.1-4.6) for men and 11.0 (95%CI=5.8-20.7) for women. Effects of chewing pan with or without tobacco on oral cancer risk were elevated for both sexes. Bidi smoking increased the risk of oral cancer in men (OR=1.9, 95%CI=1.1-3.2). Dose-response relations were observed for the frequency and duration of chewing and alcohol drinking, as well as in duration of bidi smoking. Given the relatively poor survival rates of oral cancer patients, cessation of tobacco and moderation of alcohol use remain the key elements in oral cancer prevention and control. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/17933578/Role_of_tobacco_smoking_chewing_and_alcohol_drinking_in_the_risk_of_oral_cancer_in_Trivandrum_India:_a_nested_case_control_design_using_incident_cancer_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(07)00154-6 DB - PRIME DP - Unbound Medicine ER -