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Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome.
J Atten Disord. 2008 Jan; 11(4):470-81.JA

Abstract

OBJECTIVE

This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS).

METHOD

Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks.

RESULTS

Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure.

CONCLUSION

Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS.

Authors+Show Affiliations

Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114-2696, USA. tspencer@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17934184

Citation

Spencer, Thomas J., et al. "Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome." Journal of Attention Disorders, vol. 11, no. 4, 2008, pp. 470-81.
Spencer TJ, Sallee FR, Gilbert DL, et al. Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome. J Atten Disord. 2008;11(4):470-81.
Spencer, T. J., Sallee, F. R., Gilbert, D. L., Dunn, D. W., McCracken, J. T., Coffey, B. J., Budman, C. L., Ricardi, R. K., Leonard, H. L., Allen, A. J., Milton, D. R., Feldman, P. D., Kelsey, D. K., Geller, D. A., Linder, S. L., Lewis, D. W., Winner, P. K., Kurlan, R. M., & Mintz, M. (2008). Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome. Journal of Attention Disorders, 11(4), 470-81.
Spencer TJ, et al. Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome. J Atten Disord. 2008;11(4):470-81. PubMed PMID: 17934184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome. AU - Spencer,Thomas J, AU - Sallee,F Randy, AU - Gilbert,Donald L, AU - Dunn,David W, AU - McCracken,James T, AU - Coffey,Barbara J, AU - Budman,Cathy L, AU - Ricardi,Randall K, AU - Leonard,Henrietta L, AU - Allen,Albert J, AU - Milton,Denai R, AU - Feldman,Peter D, AU - Kelsey,Douglas K, AU - Geller,Daniel A, AU - Linder,Steven L, AU - Lewis,Donald W, AU - Winner,Paul K, AU - Kurlan,Roger M, AU - Mintz,Mark, Y1 - 2007/10/12/ PY - 2007/10/16/pubmed PY - 2008/4/3/medline PY - 2007/10/16/entrez SP - 470 EP - 81 JF - Journal of attention disorders JO - J Atten Disord VL - 11 IS - 4 N2 - OBJECTIVE: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). METHOD: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. RESULTS: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. CONCLUSION: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. SN - 1087-0547 UR - https://www.unboundmedicine.com/medline/citation/17934184/Atomoxetine_treatment_of_ADHD_in_children_with_comorbid_Tourette_syndrome_ L2 - https://journals.sagepub.com/doi/10.1177/1087054707306109?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -