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B-type natriuretic peptide in patients with systemic right ventricle.
Cardiology. 2008; 110(1):1-7.C

Abstract

OBJECTIVE

To examine the diagnostic value of B-type natriuretic peptide (BNP) in patients with systemic right ventricle.

METHODS

Plasma BNP levels were measured in 48 outpatients with D-transposition of the great arteries after atrial switch procedure or congenitally corrected transposition of the great arteries.

RESULTS

Plasma BNP was < or =20 pg/ml in 52% and <200 pg/ml in all patients, significantly higher in females compared to males (p = 0.004), and positively correlated with age (r = 0.3, p = 0.04). New York Heart Association class I patients had significantly lower BNP than class II patients (p = 0.03). A positive correlation was found between BNP and severity of tricuspid regurgitation (r = 0.5, p < 0.001). Plasma BNP was weakly, negatively correlated to maximum exercise capability, peak oxygen uptake, maximum heart rate during exercise testing and minimal heart rate in the 24-hour Holter monitoring. Additionally, BNP was negatively correlated with flow velocity across the pulmonary valve in patients with congenitally corrected transposition of the great arteries (r = -0.81, p = 0.03).

CONCLUSION

Plasma BNP is normal in patients with systemic right ventricle, but increases with deterioration of clinical status and decreasing exercise capability. BNP is positively correlated with severity of tricuspid regurgitation, a prognostic factor for survival.

Authors+Show Affiliations

Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nurnberg, Erlangen, Germany. Andreas.Koch@kinder.imed.uni-erlangen.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17934262

Citation

Koch, Andreas M E., et al. "B-type Natriuretic Peptide in Patients With Systemic Right Ventricle." Cardiology, vol. 110, no. 1, 2008, pp. 1-7.
Koch AM, Zink S, Singer H. B-type natriuretic peptide in patients with systemic right ventricle. Cardiology. 2008;110(1):1-7.
Koch, A. M., Zink, S., & Singer, H. (2008). B-type natriuretic peptide in patients with systemic right ventricle. Cardiology, 110(1), 1-7.
Koch AM, Zink S, Singer H. B-type Natriuretic Peptide in Patients With Systemic Right Ventricle. Cardiology. 2008;110(1):1-7. PubMed PMID: 17934262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B-type natriuretic peptide in patients with systemic right ventricle. AU - Koch,Andreas M E, AU - Zink,Stefan, AU - Singer,Helmut, Y1 - 2007/10/10/ PY - 2006/12/28/received PY - 2007/02/09/accepted PY - 2007/10/16/pubmed PY - 2008/5/1/medline PY - 2007/10/16/entrez SP - 1 EP - 7 JF - Cardiology JO - Cardiology VL - 110 IS - 1 N2 - OBJECTIVE: To examine the diagnostic value of B-type natriuretic peptide (BNP) in patients with systemic right ventricle. METHODS: Plasma BNP levels were measured in 48 outpatients with D-transposition of the great arteries after atrial switch procedure or congenitally corrected transposition of the great arteries. RESULTS: Plasma BNP was < or =20 pg/ml in 52% and <200 pg/ml in all patients, significantly higher in females compared to males (p = 0.004), and positively correlated with age (r = 0.3, p = 0.04). New York Heart Association class I patients had significantly lower BNP than class II patients (p = 0.03). A positive correlation was found between BNP and severity of tricuspid regurgitation (r = 0.5, p < 0.001). Plasma BNP was weakly, negatively correlated to maximum exercise capability, peak oxygen uptake, maximum heart rate during exercise testing and minimal heart rate in the 24-hour Holter monitoring. Additionally, BNP was negatively correlated with flow velocity across the pulmonary valve in patients with congenitally corrected transposition of the great arteries (r = -0.81, p = 0.03). CONCLUSION: Plasma BNP is normal in patients with systemic right ventricle, but increases with deterioration of clinical status and decreasing exercise capability. BNP is positively correlated with severity of tricuspid regurgitation, a prognostic factor for survival. SN - 1421-9751 UR - https://www.unboundmedicine.com/medline/citation/17934262/B_type_natriuretic_peptide_in_patients_with_systemic_right_ventricle_ L2 - https://www.karger.com?DOI=10.1159/000109399 DB - PRIME DP - Unbound Medicine ER -