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Frequency of pertussis in children with prolongued cough.
Scand J Infect Dis. 2008; 40(4):314-9.SJ

Abstract

To determine the frequency of pertussis in children < or = 16 y who had prolonged cough (> or = 14 d), a prospective study was conducted at an outpatient clinic of a paediatric hospital. Nasopharyngeal swabs were taken for culture and nucleic acid testing by polymerase chain reaction (PCR) for Bordetella pertussis. Immunoglobulin A and immunoglobulin G antibodies against pertussis toxin (PT) were tested by ELISA in paired serum samples. A total of 148 patients were recruited during 1 y. Pertussis was detected in 25 (16.9%) patients with at least 1 of the tests. PCR was positive in 12 patients, and 9 cases was diagnosed serologically. Both PCR and serology were positive in 4 children. Duration of cough was longer in the patients with pertussis (median 33 vs 20, p = 0.03). Seropositivity of pertussis toxin was higher in pertussis negative patients during enrollment (24% vs 65%, p = 0.005). From the results of this study, B. pertussis seems to be common in our population despite high immunization rates with whole cell vaccine. Although the duration of cough is defined as longer than 21 d in some studies for pertussis case definition criteria, it was shorter than this in 3 of our cases.

Authors+Show Affiliations

Department of Paediatric Infectious Diseases, Hacettepe University School of Medicine, 06100 Sihhiye, Ankara, Turkey. inciy@hacettepe.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17934983

Citation

Yildirim, Inci, et al. "Frequency of Pertussis in Children With Prolongued Cough." Scandinavian Journal of Infectious Diseases, vol. 40, no. 4, 2008, pp. 314-9.
Yildirim I, Ceyhan M, Kalayci O, et al. Frequency of pertussis in children with prolongued cough. Scand J Infect Dis. 2008;40(4):314-9.
Yildirim, I., Ceyhan, M., Kalayci, O., Cengiz, A. B., Secmeer, G., Gur, D., & Pelton, S. (2008). Frequency of pertussis in children with prolongued cough. Scandinavian Journal of Infectious Diseases, 40(4), 314-9.
Yildirim I, et al. Frequency of Pertussis in Children With Prolongued Cough. Scand J Infect Dis. 2008;40(4):314-9. PubMed PMID: 17934983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of pertussis in children with prolongued cough. AU - Yildirim,Inci, AU - Ceyhan,Mehmet, AU - Kalayci,Omer, AU - Cengiz,Ali Bulent, AU - Secmeer,Gulten, AU - Gur,Deniz, AU - Pelton,Steve, PY - 2007/10/16/pubmed PY - 2008/9/9/medline PY - 2007/10/16/entrez SP - 314 EP - 9 JF - Scandinavian journal of infectious diseases JO - Scand J Infect Dis VL - 40 IS - 4 N2 - To determine the frequency of pertussis in children < or = 16 y who had prolonged cough (> or = 14 d), a prospective study was conducted at an outpatient clinic of a paediatric hospital. Nasopharyngeal swabs were taken for culture and nucleic acid testing by polymerase chain reaction (PCR) for Bordetella pertussis. Immunoglobulin A and immunoglobulin G antibodies against pertussis toxin (PT) were tested by ELISA in paired serum samples. A total of 148 patients were recruited during 1 y. Pertussis was detected in 25 (16.9%) patients with at least 1 of the tests. PCR was positive in 12 patients, and 9 cases was diagnosed serologically. Both PCR and serology were positive in 4 children. Duration of cough was longer in the patients with pertussis (median 33 vs 20, p = 0.03). Seropositivity of pertussis toxin was higher in pertussis negative patients during enrollment (24% vs 65%, p = 0.005). From the results of this study, B. pertussis seems to be common in our population despite high immunization rates with whole cell vaccine. Although the duration of cough is defined as longer than 21 d in some studies for pertussis case definition criteria, it was shorter than this in 3 of our cases. SN - 0036-5548 UR - https://www.unboundmedicine.com/medline/citation/17934983/Frequency_of_pertussis_in_children_with_prolongued_cough_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365540701689659 DB - PRIME DP - Unbound Medicine ER -