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The expression of receptors for endocannabinoids in human and rodent skeletal muscle.
Biochem Biophys Res Commun. 2007 Dec 07; 364(1):105-10.BB

Abstract

The endocannabinoid system is a lipid derived signalling system that has been shown to regulate appetite and energy metabolism. The most abundant endogenous endocannabinoid, anandamide, has been shown to activate the cannabinoid receptor type 1 (CB1) and type 2 (CB2) as well as the 'non-cannabinoid' transient receptor potential channel-vanilloid sub-family member 1 (TRPV1), before being rapidly metabolised by fatty acid amide hydrolase (FAAH). We have previously demonstrated the expression of CB1 and studied the effects of CB1 activation and inhibition in human skeletal muscle myotubes, however, not all results could be explained by CB1 mediated effects. This suggests that other receptors which are activated by endocannabinoids may be present in skeletal muscle. In this study we describe the presence of not only CB1, but also CB2, TRPV1 and the degrading enzyme FAAH in human and rodent skeletal muscle using reverse transcription polymerase chain reaction (RT-PCR).

Authors+Show Affiliations

Discipline of Medicine, Royal Adelaide Hospital, University of Adelaide, Level 6, Eleanor Harrald Building, Adelaide, SA 5005, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17935697

Citation

Cavuoto, Paul, et al. "The Expression of Receptors for Endocannabinoids in Human and Rodent Skeletal Muscle." Biochemical and Biophysical Research Communications, vol. 364, no. 1, 2007, pp. 105-10.
Cavuoto P, McAinch AJ, Hatzinikolas G, et al. The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochem Biophys Res Commun. 2007;364(1):105-10.
Cavuoto, P., McAinch, A. J., Hatzinikolas, G., Janovská, A., Game, P., & Wittert, G. A. (2007). The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and Biophysical Research Communications, 364(1), 105-10.
Cavuoto P, et al. The Expression of Receptors for Endocannabinoids in Human and Rodent Skeletal Muscle. Biochem Biophys Res Commun. 2007 Dec 7;364(1):105-10. PubMed PMID: 17935697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The expression of receptors for endocannabinoids in human and rodent skeletal muscle. AU - Cavuoto,Paul, AU - McAinch,Andrew J, AU - Hatzinikolas,George, AU - Janovská,Alena, AU - Game,Philip, AU - Wittert,Gary A, Y1 - 2007/10/02/ PY - 2007/09/24/received PY - 2007/09/25/accepted PY - 2007/10/16/pubmed PY - 2007/12/6/medline PY - 2007/10/16/entrez SP - 105 EP - 10 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 364 IS - 1 N2 - The endocannabinoid system is a lipid derived signalling system that has been shown to regulate appetite and energy metabolism. The most abundant endogenous endocannabinoid, anandamide, has been shown to activate the cannabinoid receptor type 1 (CB1) and type 2 (CB2) as well as the 'non-cannabinoid' transient receptor potential channel-vanilloid sub-family member 1 (TRPV1), before being rapidly metabolised by fatty acid amide hydrolase (FAAH). We have previously demonstrated the expression of CB1 and studied the effects of CB1 activation and inhibition in human skeletal muscle myotubes, however, not all results could be explained by CB1 mediated effects. This suggests that other receptors which are activated by endocannabinoids may be present in skeletal muscle. In this study we describe the presence of not only CB1, but also CB2, TRPV1 and the degrading enzyme FAAH in human and rodent skeletal muscle using reverse transcription polymerase chain reaction (RT-PCR). SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/17935697/The_expression_of_receptors_for_endocannabinoids_in_human_and_rodent_skeletal_muscle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(07)02102-X DB - PRIME DP - Unbound Medicine ER -