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The short-term and long-term effects of radical prostatectomy on lower urinary tract symptoms.
J Urol 2007; 178(6):2397-400; discussion 2400-1JU

Abstract

PURPOSE

We determined the long-term effect of radical prostatectomy on lower urinary tract symptoms.

MATERIALS AND METHODS

Between October 1, 2000 and January 30, 2003, 587 men underwent open radical retropubic prostatectomy. Of these men 453 completed the American Urological Association symptom index at baseline, and 12 and 48 months. Mean changes in American Urological Association total, voiding and storage symptom scores were ascertained between baseline and 12 months (short term), baseline and 48 months (long term), and between 12 and 48 months (natural history of lower urinary tract symptoms without a prostate). Symptom scores were ascertained independently for men with baseline mild vs moderate/severe lower urinary tract symptoms.

RESULTS

Clinically and statistically significant short-term and long-term improvements were observed in mean American Urological Association total, storage and voiding symptom scores for men presenting with moderate/severe lower urinary tract symptoms. The previously reported progression of lower urinary tract symptoms in the general population of men older than 40 years was not observed in our patients with an absent prostate.

CONCLUSIONS

The current study provides compelling evidence that radical prostatectomy prevents the progression of lower urinary tract symptoms in men with and without baseline clinically significant lower urinary tract symptoms. This beneficial effect of radical prostatectomy on the natural history of lower urinary tract symptoms should be considered when weighing the risks and benefit of the treatment option for localized prostate cancer.

Authors+Show Affiliations

Department of Urology, New York University School of Medicine, New York, New York 10016, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17936841

Citation

Slova, Denisa, and Herbert Lepor. "The Short-term and Long-term Effects of Radical Prostatectomy On Lower Urinary Tract Symptoms." The Journal of Urology, vol. 178, no. 6, 2007, pp. 2397-400; discussion 2400-1.
Slova D, Lepor H. The short-term and long-term effects of radical prostatectomy on lower urinary tract symptoms. J Urol. 2007;178(6):2397-400; discussion 2400-1.
Slova, D., & Lepor, H. (2007). The short-term and long-term effects of radical prostatectomy on lower urinary tract symptoms. The Journal of Urology, 178(6), pp. 2397-400; discussion 2400-1.
Slova D, Lepor H. The Short-term and Long-term Effects of Radical Prostatectomy On Lower Urinary Tract Symptoms. J Urol. 2007;178(6):2397-400; discussion 2400-1. PubMed PMID: 17936841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The short-term and long-term effects of radical prostatectomy on lower urinary tract symptoms. AU - Slova,Denisa, AU - Lepor,Herbert, Y1 - 2007/10/22/ PY - 2007/03/14/received PY - 2007/10/16/pubmed PY - 2008/1/5/medline PY - 2007/10/16/entrez SP - 2397-400; discussion 2400-1 JF - The Journal of urology JO - J. Urol. VL - 178 IS - 6 N2 - PURPOSE: We determined the long-term effect of radical prostatectomy on lower urinary tract symptoms. MATERIALS AND METHODS: Between October 1, 2000 and January 30, 2003, 587 men underwent open radical retropubic prostatectomy. Of these men 453 completed the American Urological Association symptom index at baseline, and 12 and 48 months. Mean changes in American Urological Association total, voiding and storage symptom scores were ascertained between baseline and 12 months (short term), baseline and 48 months (long term), and between 12 and 48 months (natural history of lower urinary tract symptoms without a prostate). Symptom scores were ascertained independently for men with baseline mild vs moderate/severe lower urinary tract symptoms. RESULTS: Clinically and statistically significant short-term and long-term improvements were observed in mean American Urological Association total, storage and voiding symptom scores for men presenting with moderate/severe lower urinary tract symptoms. The previously reported progression of lower urinary tract symptoms in the general population of men older than 40 years was not observed in our patients with an absent prostate. CONCLUSIONS: The current study provides compelling evidence that radical prostatectomy prevents the progression of lower urinary tract symptoms in men with and without baseline clinically significant lower urinary tract symptoms. This beneficial effect of radical prostatectomy on the natural history of lower urinary tract symptoms should be considered when weighing the risks and benefit of the treatment option for localized prostate cancer. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/17936841/The_short_term_and_long_term_effects_of_radical_prostatectomy_on_lower_urinary_tract_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(07)01975-1 DB - PRIME DP - Unbound Medicine ER -