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Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action.
Pharmacol Biochem Behav. 2008 Feb; 88(4):418-26.PB

Abstract

This study investigated the possible antidepressant-like and anxiolytic-like effects of diphenyl diselenide, (PhSe)(2) in mice. The involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the antidepressant-like effect was also evaluated. The immobility times in the tail suspension test (TST) and forced swimming test (FST) were reduced by (PhSe)(2) (5-100 mg/kg; oral route, p.o.). The antiimmobility effect of (PhSe)(2) (5 mg/kg, p.o.) in the TST was prevented by pretreatment of mice with L-arginine [a substrate for nitric oxide synthase (NOS)], methylene blue [an inhibitor of NO synthase and sGC] and sildenafil [a phosphodiesterase 5 inhibitor]. Furthermore, a sub-effective dose of (PhSe)(2) (0.1 mg/kg, p.o.) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine [L-NNA; 0.3mg/kg, i.p. inhibitor of NOS], (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ; 30 pmol/site i.c.v., a specific inhibitor of soluble guanylate cyclase (sGC)], fluoxetine and imipramine in the TST. (PhSe)(2) (50-100 mg/kg, p.o.) induced anxiolytic-like effect in the elevated plus-maze test and light/dark box. Together the results indicate that (PhSe)(2) elicited significant antidepressant-like and anxiolytic-like effects. The antidepressant-like action caused by (PhSe)(2) seems to involve an interaction with L-arginine-NO-cGMP pathway.

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17936885

Citation

Savegnago, Lucielli, et al. "Diphenyl Diselenide Exerts Antidepressant-like and Anxiolytic-like Effects in Mice: Involvement of L-arginine-nitric Oxide-soluble Guanylate Cyclase Pathway in Its Antidepressant-like Action." Pharmacology, Biochemistry, and Behavior, vol. 88, no. 4, 2008, pp. 418-26.
Savegnago L, Jesse CR, Pinto LG, et al. Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action. Pharmacol Biochem Behav. 2008;88(4):418-26.
Savegnago, L., Jesse, C. R., Pinto, L. G., Rocha, J. B., Barancelli, D. A., Nogueira, C. W., & Zeni, G. (2008). Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action. Pharmacology, Biochemistry, and Behavior, 88(4), 418-26.
Savegnago L, et al. Diphenyl Diselenide Exerts Antidepressant-like and Anxiolytic-like Effects in Mice: Involvement of L-arginine-nitric Oxide-soluble Guanylate Cyclase Pathway in Its Antidepressant-like Action. Pharmacol Biochem Behav. 2008;88(4):418-26. PubMed PMID: 17936885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action. AU - Savegnago,Lucielli, AU - Jesse,Cristiano Ricardo, AU - Pinto,Larissa Garcia, AU - Rocha,Joao Batista Teixeira, AU - Barancelli,Daniela Aline, AU - Nogueira,Cristina Wayne, AU - Zeni,Gilson, Y1 - 2007/09/29/ PY - 2007/02/01/received PY - 2007/07/10/revised PY - 2007/09/21/accepted PY - 2007/10/16/pubmed PY - 2008/5/9/medline PY - 2007/10/16/entrez SP - 418 EP - 26 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 88 IS - 4 N2 - This study investigated the possible antidepressant-like and anxiolytic-like effects of diphenyl diselenide, (PhSe)(2) in mice. The involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the antidepressant-like effect was also evaluated. The immobility times in the tail suspension test (TST) and forced swimming test (FST) were reduced by (PhSe)(2) (5-100 mg/kg; oral route, p.o.). The antiimmobility effect of (PhSe)(2) (5 mg/kg, p.o.) in the TST was prevented by pretreatment of mice with L-arginine [a substrate for nitric oxide synthase (NOS)], methylene blue [an inhibitor of NO synthase and sGC] and sildenafil [a phosphodiesterase 5 inhibitor]. Furthermore, a sub-effective dose of (PhSe)(2) (0.1 mg/kg, p.o.) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine [L-NNA; 0.3mg/kg, i.p. inhibitor of NOS], (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ; 30 pmol/site i.c.v., a specific inhibitor of soluble guanylate cyclase (sGC)], fluoxetine and imipramine in the TST. (PhSe)(2) (50-100 mg/kg, p.o.) induced anxiolytic-like effect in the elevated plus-maze test and light/dark box. Together the results indicate that (PhSe)(2) elicited significant antidepressant-like and anxiolytic-like effects. The antidepressant-like action caused by (PhSe)(2) seems to involve an interaction with L-arginine-NO-cGMP pathway. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/17936885/Diphenyl_diselenide_exerts_antidepressant_like_and_anxiolytic_like_effects_in_mice:_involvement_of_L_arginine_nitric_oxide_soluble_guanylate_cyclase_pathway_in_its_antidepressant_like_action_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(07)00306-1 DB - PRIME DP - Unbound Medicine ER -