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Cockroach allergen levels and associations with cockroach-specific IgE.
J Allergy Clin Immunol 2008; 121(1):240-5JA

Abstract

BACKGROUND

Among inner-city children with asthma, cockroach allergen exposure has been associated with allergic sensitization.

OBJECTIVE

We hypothesized that cockroach allergen levels in homes would be associated with sensitization to cockroach allergens in children.

METHODS

From a low-income preschool program, 341 four-year-old children selected on the basis of the willingness of their caregivers to participate in the study were enrolled. Dust from their beds and kitchens were analyzed for cockroach (Bla g 2), mouse (mouse urinary proteins), and cat allergens (Fel d 1). Serum samples were analyzed for allergen-specific IgE antibodies by immunoassay.

RESULTS

Bla g 2 levels >1 U/g in children's bed and kitchen dust samples were independently associated with cockroach-specific IgE (odds ratio [OR], 2.7; 95% CI, 1.1-6.4; and OR, 3.4; 95% CI, 1.2-9.4, respectively), adjusting for sex, ethnicity, asthma, pet ownership, mother's allergic sensitization, environmental tobacco smoke, and having lived in other homes. Bla g 2 was associated (OR, 3.6; 95% CI, 1.0-13.1) with cockroach-specific IgE among children with asthma. Among children without asthma, the ORs were similar (OR, 3.0; 95% CI, 0.9-10.3), but the association was not statistically significant.

CONCLUSION

Concentrations of the major cockroach allergen, Bla g 2, in settled dust were associated with cockroach-specific IgE independent of other factors in a cohort of 4-year-old inner-city children.

Authors+Show Affiliations

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. cg288@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17936887

Citation

Chew, Ginger L., et al. "Cockroach Allergen Levels and Associations With Cockroach-specific IgE." The Journal of Allergy and Clinical Immunology, vol. 121, no. 1, 2008, pp. 240-5.
Chew GL, Perzanowski MS, Canfield SM, et al. Cockroach allergen levels and associations with cockroach-specific IgE. J Allergy Clin Immunol. 2008;121(1):240-5.
Chew, G. L., Perzanowski, M. S., Canfield, S. M., Goldstein, I. F., Mellins, R. B., Hoepner, L. A., ... Jacobson, J. S. (2008). Cockroach allergen levels and associations with cockroach-specific IgE. The Journal of Allergy and Clinical Immunology, 121(1), pp. 240-5.
Chew GL, et al. Cockroach Allergen Levels and Associations With Cockroach-specific IgE. J Allergy Clin Immunol. 2008;121(1):240-5. PubMed PMID: 17936887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cockroach allergen levels and associations with cockroach-specific IgE. AU - Chew,Ginger L, AU - Perzanowski,Matthew S, AU - Canfield,Stephen M, AU - Goldstein,Inge F, AU - Mellins,Robert B, AU - Hoepner,Lori A, AU - Ashby-Thompson,Maxine, AU - Jacobson,Judith S, Y1 - 2007/10/22/ PY - 2007/05/08/received PY - 2007/08/13/revised PY - 2007/08/14/accepted PY - 2007/10/16/pubmed PY - 2008/2/26/medline PY - 2007/10/16/entrez SP - 240 EP - 5 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 121 IS - 1 N2 - BACKGROUND: Among inner-city children with asthma, cockroach allergen exposure has been associated with allergic sensitization. OBJECTIVE: We hypothesized that cockroach allergen levels in homes would be associated with sensitization to cockroach allergens in children. METHODS: From a low-income preschool program, 341 four-year-old children selected on the basis of the willingness of their caregivers to participate in the study were enrolled. Dust from their beds and kitchens were analyzed for cockroach (Bla g 2), mouse (mouse urinary proteins), and cat allergens (Fel d 1). Serum samples were analyzed for allergen-specific IgE antibodies by immunoassay. RESULTS: Bla g 2 levels >1 U/g in children's bed and kitchen dust samples were independently associated with cockroach-specific IgE (odds ratio [OR], 2.7; 95% CI, 1.1-6.4; and OR, 3.4; 95% CI, 1.2-9.4, respectively), adjusting for sex, ethnicity, asthma, pet ownership, mother's allergic sensitization, environmental tobacco smoke, and having lived in other homes. Bla g 2 was associated (OR, 3.6; 95% CI, 1.0-13.1) with cockroach-specific IgE among children with asthma. Among children without asthma, the ORs were similar (OR, 3.0; 95% CI, 0.9-10.3), but the association was not statistically significant. CONCLUSION: Concentrations of the major cockroach allergen, Bla g 2, in settled dust were associated with cockroach-specific IgE independent of other factors in a cohort of 4-year-old inner-city children. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/17936887/Cockroach_allergen_levels_and_associations_with_cockroach_specific_IgE_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(07)01590-4 DB - PRIME DP - Unbound Medicine ER -