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Anticentromere antibodies identify patients with Sjögren's syndrome and autoimmune overlap syndrome.
J Rheumatol 2007; 34(11):2253-8JR

Abstract

OBJECTIVE

To assess the prevalence and clinical and immunological significance of anticentromere antibodies (ACA) in patients with primary Sjögren's syndrome (pSS).

METHODS

We retrospectively investigated the prevalence of ACA in patients with SS. We compared ACA-positive SS patients with ACA-negative pSS patients.

RESULTS

The prevalence of ACA among patients with pSS was 4.7% (10/212). Among the patients with SS and an associated autoimmune disease, 10 patients had ACA and limited cutaneous sclerosis (SSc). Clinical and immunological patterns did not differ between the 10 pSS patients with ACA alone and the 10 SS patients with ACA and SSc, except for presence of limited cutaneous SSc (lcSSc). Moreover, all ACA-positive sera recognized centromere protein-B on ELISA, regardless of the presence of SSc. The entire SS-ACA group (n = 20) showed greater frequency of Raynaud's phenomenon, objective xerophthalmia, peripheral neuropathy, and additional autoimmune disorders, especially primary biliary cirrhosis, compared to pSS patients without ACA (p = 0.005, p = 0.04, p = 0.001, p = 0.05, p < 0.0001, respectively). SS patients with ACA less frequently showed anti-SSA or anti-SSB antibodies than those without ACA (p = 0.0002, p = 0.01, respectively) but greater prevalence of autoantibodies other than anti-SSA/SSB or ACA (p = 0.001).

CONCLUSION

Clinical and immunological features of SS were largely similar among SS patients with ACA with and without SSc. However, the presence of ACA among patients with SS allows identification of a subset of patients with "SS overlap syndrome," who show a wide diversity of autoimmunity, encompassing but not limited to SSc.

Authors+Show Affiliations

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Service de Rhumatologie, Université Paris-Sud 11, 78 rue de Général Leclerc, Le Kremlin-Bicêtre, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17937465

Citation

Salliot, Carine, et al. "Anticentromere Antibodies Identify Patients With Sjögren's Syndrome and Autoimmune Overlap Syndrome." The Journal of Rheumatology, vol. 34, no. 11, 2007, pp. 2253-8.
Salliot C, Gottenberg JE, Bengoufa D, et al. Anticentromere antibodies identify patients with Sjögren's syndrome and autoimmune overlap syndrome. J Rheumatol. 2007;34(11):2253-8.
Salliot, C., Gottenberg, J. E., Bengoufa, D., Desmoulins, F., Miceli-Richard, C., & Mariette, X. (2007). Anticentromere antibodies identify patients with Sjögren's syndrome and autoimmune overlap syndrome. The Journal of Rheumatology, 34(11), pp. 2253-8.
Salliot C, et al. Anticentromere Antibodies Identify Patients With Sjögren's Syndrome and Autoimmune Overlap Syndrome. J Rheumatol. 2007;34(11):2253-8. PubMed PMID: 17937465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticentromere antibodies identify patients with Sjögren's syndrome and autoimmune overlap syndrome. AU - Salliot,Carine, AU - Gottenberg,Jacques-Eric, AU - Bengoufa,Djaouida, AU - Desmoulins,Frédéric, AU - Miceli-Richard,Corinne, AU - Mariette,Xavier, Y1 - 2007/10/15/ PY - 2007/10/17/pubmed PY - 2008/2/2/medline PY - 2007/10/17/entrez SP - 2253 EP - 8 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 34 IS - 11 N2 - OBJECTIVE: To assess the prevalence and clinical and immunological significance of anticentromere antibodies (ACA) in patients with primary Sjögren's syndrome (pSS). METHODS: We retrospectively investigated the prevalence of ACA in patients with SS. We compared ACA-positive SS patients with ACA-negative pSS patients. RESULTS: The prevalence of ACA among patients with pSS was 4.7% (10/212). Among the patients with SS and an associated autoimmune disease, 10 patients had ACA and limited cutaneous sclerosis (SSc). Clinical and immunological patterns did not differ between the 10 pSS patients with ACA alone and the 10 SS patients with ACA and SSc, except for presence of limited cutaneous SSc (lcSSc). Moreover, all ACA-positive sera recognized centromere protein-B on ELISA, regardless of the presence of SSc. The entire SS-ACA group (n = 20) showed greater frequency of Raynaud's phenomenon, objective xerophthalmia, peripheral neuropathy, and additional autoimmune disorders, especially primary biliary cirrhosis, compared to pSS patients without ACA (p = 0.005, p = 0.04, p = 0.001, p = 0.05, p < 0.0001, respectively). SS patients with ACA less frequently showed anti-SSA or anti-SSB antibodies than those without ACA (p = 0.0002, p = 0.01, respectively) but greater prevalence of autoantibodies other than anti-SSA/SSB or ACA (p = 0.001). CONCLUSION: Clinical and immunological features of SS were largely similar among SS patients with ACA with and without SSc. However, the presence of ACA among patients with SS allows identification of a subset of patients with "SS overlap syndrome," who show a wide diversity of autoimmunity, encompassing but not limited to SSc. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/17937465/Anticentromere_antibodies_identify_patients_with_Sjögren's_syndrome_and_autoimmune_overlap_syndrome_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=17937465 DB - PRIME DP - Unbound Medicine ER -