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The genetics of hereditary colon cancer.
Genes Dev 2007; 21(20):2525-38GD

Abstract

The genetic basis of sporadic colorectal cancer has illuminated our knowledge of human cancer genetics. This has been facilitated and catalyzed by an appreciation and deep understanding of the forms of colorectal cancer that harbor an inherited predisposition, including familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome, the hamartomatous polyposis syndromes, and certain other rare syndromes. Identification of germline mutations in pivotal genes underlying the inherited forms of colorectal cancer has yielded many dividends, including functional dissection of critical molecular pathways that have been revealed to be important in development, cellular homeostasis, and cancer; new approaches in chemoprevention, molecular diagnostics and genetic testing, and therapy; and underscoring genotypic-phenotypic relationships.

Authors+Show Affiliations

Dapartment of Medicine (Gastrointestinal), University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. anil2@mail.med.upenn.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17938238

Citation

Rustgi, Anil K.. "The Genetics of Hereditary Colon Cancer." Genes & Development, vol. 21, no. 20, 2007, pp. 2525-38.
Rustgi AK. The genetics of hereditary colon cancer. Genes Dev. 2007;21(20):2525-38.
Rustgi, A. K. (2007). The genetics of hereditary colon cancer. Genes & Development, 21(20), pp. 2525-38.
Rustgi AK. The Genetics of Hereditary Colon Cancer. Genes Dev. 2007 Oct 15;21(20):2525-38. PubMed PMID: 17938238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetics of hereditary colon cancer. A1 - Rustgi,Anil K, PY - 2007/10/17/pubmed PY - 2007/12/6/medline PY - 2007/10/17/entrez SP - 2525 EP - 38 JF - Genes & development JO - Genes Dev. VL - 21 IS - 20 N2 - The genetic basis of sporadic colorectal cancer has illuminated our knowledge of human cancer genetics. This has been facilitated and catalyzed by an appreciation and deep understanding of the forms of colorectal cancer that harbor an inherited predisposition, including familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome, the hamartomatous polyposis syndromes, and certain other rare syndromes. Identification of germline mutations in pivotal genes underlying the inherited forms of colorectal cancer has yielded many dividends, including functional dissection of critical molecular pathways that have been revealed to be important in development, cellular homeostasis, and cancer; new approaches in chemoprevention, molecular diagnostics and genetic testing, and therapy; and underscoring genotypic-phenotypic relationships. SN - 0890-9369 UR - https://www.unboundmedicine.com/medline/citation/17938238/The_genetics_of_hereditary_colon_cancer_ L2 - http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=17938238 DB - PRIME DP - Unbound Medicine ER -