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Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix.
Arch Dermatol. 2007 Oct; 143(10):1310-3.AD

Abstract

BACKGROUND

The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion.

OBSERVATIONS

We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity.

CONCLUSION

This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.

Authors+Show Affiliations

Department of Dermatology, University of Pisa, Pisa, Italy. m.romanelli@med.unipi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17938346

Citation

Romanelli, Marco, et al. "Hydroxyurea-induced Leg Ulcers Treated With a Protease-modulating Matrix." Archives of Dermatology, vol. 143, no. 10, 2007, pp. 1310-3.
Romanelli M, Dini V, Romanelli P. Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. Arch Dermatol. 2007;143(10):1310-3.
Romanelli, M., Dini, V., & Romanelli, P. (2007). Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. Archives of Dermatology, 143(10), 1310-3.
Romanelli M, Dini V, Romanelli P. Hydroxyurea-induced Leg Ulcers Treated With a Protease-modulating Matrix. Arch Dermatol. 2007;143(10):1310-3. PubMed PMID: 17938346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. AU - Romanelli,Marco, AU - Dini,Valentina, AU - Romanelli,Paolo, PY - 2007/10/17/pubmed PY - 2007/11/14/medline PY - 2007/10/17/entrez SP - 1310 EP - 3 JF - Archives of dermatology JO - Arch Dermatol VL - 143 IS - 10 N2 - BACKGROUND: The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. OBSERVATIONS: We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity. CONCLUSION: This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/17938346/Hydroxyurea_induced_leg_ulcers_treated_with_a_protease_modulating_matrix_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archderm.143.10.1310 DB - PRIME DP - Unbound Medicine ER -