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Diabetes and cardiovascular disease: explaining the relationship.
Rev Cardiovasc Med. 2007 Summer; 8(3):145-53.RC

Abstract

Diabetes is a risk factor for cardiovascular disease. However, even elevated glucose levels below the diabetic range increase cardiovascular risk. There are several possible explanations for this relationship. First, glucose and its metabolites have direct toxic effects on vascular endothelium. Second, abnormal glucose is evidence of absolute or relative insulin deficiency, which can predispose patients to cardiovascular disease via endothelial dysfunction, lipid abnormalities, and inflammation. Third, antecedent factors, such as toxins, abnormal energy storage, and hypertension, may contribute to the development of both diabetes and cardiovascular disease. Whether glucose lowering can reduce the risk of cardiovascular disease is currently being studied in a number of large trials.

Authors+Show Affiliations

Punthakee Z
Division of Endocrinology and Metabolism, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Werstuck GH
No affiliation info available
Gerstein HC
No affiliation info available

MeSH

Blood GlucoseCardiovascular DiseasesDiabetes ComplicationsEndothelium, VascularHumansHyperglycemiaHypertensionInflammationInsulinRisk FactorsUnited States

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17938614

Citation

Punthakee, Zubin, et al. "Diabetes and Cardiovascular Disease: Explaining the Relationship." Reviews in Cardiovascular Medicine, vol. 8, no. 3, 2007, pp. 145-53.
Punthakee Z, Werstuck GH, Gerstein HC. Diabetes and cardiovascular disease: explaining the relationship. Rev Cardiovasc Med. 2007;8(3):145-53.
Punthakee, Z., Werstuck, G. H., & Gerstein, H. C. (2007). Diabetes and cardiovascular disease: explaining the relationship. Reviews in Cardiovascular Medicine, 8(3), 145-53.
Punthakee Z, Werstuck GH, Gerstein HC. Diabetes and Cardiovascular Disease: Explaining the Relationship. Rev Cardiovasc Med. 2007;8(3):145-53. PubMed PMID: 17938614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes and cardiovascular disease: explaining the relationship. AU - Punthakee,Zubin, AU - Werstuck,Geoff H, AU - Gerstein,Hertzel C, PY - 2007/10/17/pubmed PY - 2008/5/9/medline PY - 2007/10/17/entrez SP - 145 EP - 53 JF - Reviews in cardiovascular medicine JO - Rev Cardiovasc Med VL - 8 IS - 3 N2 - Diabetes is a risk factor for cardiovascular disease. However, even elevated glucose levels below the diabetic range increase cardiovascular risk. There are several possible explanations for this relationship. First, glucose and its metabolites have direct toxic effects on vascular endothelium. Second, abnormal glucose is evidence of absolute or relative insulin deficiency, which can predispose patients to cardiovascular disease via endothelial dysfunction, lipid abnormalities, and inflammation. Third, antecedent factors, such as toxins, abnormal energy storage, and hypertension, may contribute to the development of both diabetes and cardiovascular disease. Whether glucose lowering can reduce the risk of cardiovascular disease is currently being studied in a number of large trials. SN - 1530-6550 UR - https://www.unboundmedicine.com/medline/citation/17938614/Diabetes_and_cardiovascular_disease:_explaining_the_relationship_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -