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Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion.
Urol Int. 2007; 79(3):248-54.UI

Abstract

INTRODUCTION

Numerous studies performed in recent years have shown protective effects of N-acetylcysteine (NAC) on cardiac and renal tissue damage following ischemia/reperfusion injury. We assessed the effectiveness of systemic administration of NAC, at a therapeutic dose, in a rat model of a 1-hour 720-degree testicular torsion/detorsion.

MATERIALS AND METHODS

Sprague-Dawley rats were divided into five groups, 14 animals in each: group 1 animals underwent sham operation as the control group; group 2 rats underwent torsion/detorsion and received saline injection, and the animals in groups 3, 4, and 5 received intraperitoneal injections of 150 mg/kg NAC 30 min before torsion, after torsion, and after detorsion, respectively. Markers of oxidative stress as well as germ cell apoptosis indices were assessed 4 and 24 h after detorsion, respectively.

RESULTS

The apoptosis indices were significantly higher in group 2 as compared with the control group. Four hours after detorsion, the testicular level of lipid peroxidation was significantly increased, and antioxidant enzyme activities were significantly decreased in group 2 as compared with the controls. Administration of NAC either 30 min before or after torsion (groups 3 and 4) significantly improved the germ cell apoptosis indices and oxidant/antioxidant balance. Administration of NAC after detorsion had no significant effect on biochemical markers or germ cell apoptosis.

CONCLUSION

Administration of NAC prior to torsion or detorsion, but not after detorsion, induces protective effects against ischemia/reperfusion injury in a rat model of testicular torsion.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17940358

Citation

Payabvash, Seyedmehdi, et al. "Salutary Effects of N-acetylcysteine On Apoptotic Damage in a Rat Model of Testicular Torsion." Urologia Internationalis, vol. 79, no. 3, 2007, pp. 248-54.
Payabvash S, Salmasi AH, Kiumehr S, et al. Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion. Urol Int. 2007;79(3):248-54.
Payabvash, S., Salmasi, A. H., Kiumehr, S., Tavangar, S. M., Nourbakhsh, B., Faghihi, S. H., & Dehpour, A. R. (2007). Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion. Urologia Internationalis, 79(3), 248-54.
Payabvash S, et al. Salutary Effects of N-acetylcysteine On Apoptotic Damage in a Rat Model of Testicular Torsion. Urol Int. 2007;79(3):248-54. PubMed PMID: 17940358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion. AU - Payabvash,Seyedmehdi, AU - Salmasi,Amirali Hassanzadeh, AU - Kiumehr,Saman, AU - Tavangar,Seyed Mohammad, AU - Nourbakhsh,Bardia, AU - Faghihi,Seyed Hamed, AU - Dehpour,Ahmad Reza, PY - 2006/05/17/received PY - 2006/10/11/accepted PY - 2007/10/18/pubmed PY - 2007/11/9/medline PY - 2007/10/18/entrez SP - 248 EP - 54 JF - Urologia internationalis JO - Urol Int VL - 79 IS - 3 N2 - INTRODUCTION: Numerous studies performed in recent years have shown protective effects of N-acetylcysteine (NAC) on cardiac and renal tissue damage following ischemia/reperfusion injury. We assessed the effectiveness of systemic administration of NAC, at a therapeutic dose, in a rat model of a 1-hour 720-degree testicular torsion/detorsion. MATERIALS AND METHODS: Sprague-Dawley rats were divided into five groups, 14 animals in each: group 1 animals underwent sham operation as the control group; group 2 rats underwent torsion/detorsion and received saline injection, and the animals in groups 3, 4, and 5 received intraperitoneal injections of 150 mg/kg NAC 30 min before torsion, after torsion, and after detorsion, respectively. Markers of oxidative stress as well as germ cell apoptosis indices were assessed 4 and 24 h after detorsion, respectively. RESULTS: The apoptosis indices were significantly higher in group 2 as compared with the control group. Four hours after detorsion, the testicular level of lipid peroxidation was significantly increased, and antioxidant enzyme activities were significantly decreased in group 2 as compared with the controls. Administration of NAC either 30 min before or after torsion (groups 3 and 4) significantly improved the germ cell apoptosis indices and oxidant/antioxidant balance. Administration of NAC after detorsion had no significant effect on biochemical markers or germ cell apoptosis. CONCLUSION: Administration of NAC prior to torsion or detorsion, but not after detorsion, induces protective effects against ischemia/reperfusion injury in a rat model of testicular torsion. SN - 1423-0399 UR - https://www.unboundmedicine.com/medline/citation/17940358/Salutary_effects_of_N_acetylcysteine_on_apoptotic_damage_in_a_rat_model_of_testicular_torsion_ L2 - https://www.karger.com?DOI=10.1159/000107958 DB - PRIME DP - Unbound Medicine ER -