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Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination.
J Thromb Thrombolysis 2008; 26(1):35-40JT

Abstract

BACKGROUND

Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE.

METHODS

Demographics, symptoms, risk factors, prophylaxis, and initial management of 668 (12%) patients with COPD were compared to 3,907 patients without COPD from a prospective registry of 5,451 consecutive patients with ultrasound-confirmed DVT at 183 institutions in the United States.

RESULTS

COPD patients with DVT were older (median 72.5 years vs. 68.0 years, P < 0.0001) and more likely to be male (52.3% vs. 44.8%, P = 0.0004). They were more likely to be inpatients at the time of diagnosis of DVT (62.0% vs. 51.9%, P < 0.0001). COPD patients were more likely to be admitted to the intensive care unit (ICU) (27.7% vs.19.8%, P = 0.0003), more likely to require mechanical ventilation (23.2% vs. 13.6%, P < 0.0001), and more likely to receive inferior vena caval (IVC) filters (19.1% vs. 15.1%, P = 0.009). COPD patients more often had concomitant pulmonary embolism (PE) (22.8% vs.17.8%, P = 0.005) as well as concomitant congestive heart failure (29.5% vs. 12.5%, P < 0.0001).

CONCLUSIONS

DVT patients with COPD have a greater medical acuity than other DVT patients. This results in more frequent IVC filter insertion.

Authors+Show Affiliations

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17940729

Citation

Shetty, Ranjith, et al. "Chronic Obstructive Pulmonary Disease and Deep Vein Thrombosis: a Prevalent Combination." Journal of Thrombosis and Thrombolysis, vol. 26, no. 1, 2008, pp. 35-40.
Shetty R, Seddighzadeh A, Piazza G, et al. Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. J Thromb Thrombolysis. 2008;26(1):35-40.
Shetty, R., Seddighzadeh, A., Piazza, G., & Goldhaber, S. Z. (2008). Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. Journal of Thrombosis and Thrombolysis, 26(1), pp. 35-40.
Shetty R, et al. Chronic Obstructive Pulmonary Disease and Deep Vein Thrombosis: a Prevalent Combination. J Thromb Thrombolysis. 2008;26(1):35-40. PubMed PMID: 17940729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. AU - Shetty,Ranjith, AU - Seddighzadeh,Ali, AU - Piazza,Gregory, AU - Goldhaber,Samuel Z, Y1 - 2007/10/17/ PY - 2007/05/28/received PY - 2007/10/01/accepted PY - 2007/10/18/pubmed PY - 2008/9/26/medline PY - 2007/10/18/entrez SP - 35 EP - 40 JF - Journal of thrombosis and thrombolysis JO - J. Thromb. Thrombolysis VL - 26 IS - 1 N2 - BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE. METHODS: Demographics, symptoms, risk factors, prophylaxis, and initial management of 668 (12%) patients with COPD were compared to 3,907 patients without COPD from a prospective registry of 5,451 consecutive patients with ultrasound-confirmed DVT at 183 institutions in the United States. RESULTS: COPD patients with DVT were older (median 72.5 years vs. 68.0 years, P < 0.0001) and more likely to be male (52.3% vs. 44.8%, P = 0.0004). They were more likely to be inpatients at the time of diagnosis of DVT (62.0% vs. 51.9%, P < 0.0001). COPD patients were more likely to be admitted to the intensive care unit (ICU) (27.7% vs.19.8%, P = 0.0003), more likely to require mechanical ventilation (23.2% vs. 13.6%, P < 0.0001), and more likely to receive inferior vena caval (IVC) filters (19.1% vs. 15.1%, P = 0.009). COPD patients more often had concomitant pulmonary embolism (PE) (22.8% vs.17.8%, P = 0.005) as well as concomitant congestive heart failure (29.5% vs. 12.5%, P < 0.0001). CONCLUSIONS: DVT patients with COPD have a greater medical acuity than other DVT patients. This results in more frequent IVC filter insertion. SN - 0929-5305 UR - https://www.unboundmedicine.com/medline/citation/17940729/Chronic_obstructive_pulmonary_disease_and_deep_vein_thrombosis:_a_prevalent_combination_ L2 - https://doi.org/10.1007/s11239-007-0157-y DB - PRIME DP - Unbound Medicine ER -