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Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination.

Abstract

BACKGROUND

Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE.

METHODS

Demographics, symptoms, risk factors, prophylaxis, and initial management of 668 (12%) patients with COPD were compared to 3,907 patients without COPD from a prospective registry of 5,451 consecutive patients with ultrasound-confirmed DVT at 183 institutions in the United States.

RESULTS

COPD patients with DVT were older (median 72.5 years vs. 68.0 years, P < 0.0001) and more likely to be male (52.3% vs. 44.8%, P = 0.0004). They were more likely to be inpatients at the time of diagnosis of DVT (62.0% vs. 51.9%, P < 0.0001). COPD patients were more likely to be admitted to the intensive care unit (ICU) (27.7% vs.19.8%, P = 0.0003), more likely to require mechanical ventilation (23.2% vs. 13.6%, P < 0.0001), and more likely to receive inferior vena caval (IVC) filters (19.1% vs. 15.1%, P = 0.009). COPD patients more often had concomitant pulmonary embolism (PE) (22.8% vs.17.8%, P = 0.005) as well as concomitant congestive heart failure (29.5% vs. 12.5%, P < 0.0001).

CONCLUSIONS

DVT patients with COPD have a greater medical acuity than other DVT patients. This results in more frequent IVC filter insertion.

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  • Authors+Show Affiliations

    ,

    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

    , ,

    Source

    MeSH

    Age Factors
    Aged
    Critical Care
    Female
    Heart Failure
    Humans
    Inpatients
    Male
    Middle Aged
    Prevalence
    Prospective Studies
    Pulmonary Disease, Chronic Obstructive
    Pulmonary Embolism
    Registries
    Respiration, Artificial
    Risk Assessment
    Risk Factors
    Sex Factors
    Ultrasonography
    United States
    Vena Cava Filters
    Venous Thromboembolism
    Venous Thrombosis

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17940729

    Citation

    Shetty, Ranjith, et al. "Chronic Obstructive Pulmonary Disease and Deep Vein Thrombosis: a Prevalent Combination." Journal of Thrombosis and Thrombolysis, vol. 26, no. 1, 2008, pp. 35-40.
    Shetty R, Seddighzadeh A, Piazza G, et al. Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. J Thromb Thrombolysis. 2008;26(1):35-40.
    Shetty, R., Seddighzadeh, A., Piazza, G., & Goldhaber, S. Z. (2008). Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. Journal of Thrombosis and Thrombolysis, 26(1), pp. 35-40.
    Shetty R, et al. Chronic Obstructive Pulmonary Disease and Deep Vein Thrombosis: a Prevalent Combination. J Thromb Thrombolysis. 2008;26(1):35-40. PubMed PMID: 17940729.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. AU - Shetty,Ranjith, AU - Seddighzadeh,Ali, AU - Piazza,Gregory, AU - Goldhaber,Samuel Z, Y1 - 2007/10/17/ PY - 2007/05/28/received PY - 2007/10/01/accepted PY - 2007/10/18/pubmed PY - 2008/9/26/medline PY - 2007/10/18/entrez SP - 35 EP - 40 JF - Journal of thrombosis and thrombolysis JO - J. Thromb. Thrombolysis VL - 26 IS - 1 N2 - BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE. METHODS: Demographics, symptoms, risk factors, prophylaxis, and initial management of 668 (12%) patients with COPD were compared to 3,907 patients without COPD from a prospective registry of 5,451 consecutive patients with ultrasound-confirmed DVT at 183 institutions in the United States. RESULTS: COPD patients with DVT were older (median 72.5 years vs. 68.0 years, P < 0.0001) and more likely to be male (52.3% vs. 44.8%, P = 0.0004). They were more likely to be inpatients at the time of diagnosis of DVT (62.0% vs. 51.9%, P < 0.0001). COPD patients were more likely to be admitted to the intensive care unit (ICU) (27.7% vs.19.8%, P = 0.0003), more likely to require mechanical ventilation (23.2% vs. 13.6%, P < 0.0001), and more likely to receive inferior vena caval (IVC) filters (19.1% vs. 15.1%, P = 0.009). COPD patients more often had concomitant pulmonary embolism (PE) (22.8% vs.17.8%, P = 0.005) as well as concomitant congestive heart failure (29.5% vs. 12.5%, P < 0.0001). CONCLUSIONS: DVT patients with COPD have a greater medical acuity than other DVT patients. This results in more frequent IVC filter insertion. SN - 0929-5305 UR - https://www.unboundmedicine.com/medline/citation/17940729/Chronic_obstructive_pulmonary_disease_and_deep_vein_thrombosis:_a_prevalent_combination_ L2 - https://doi.org/10.1007/s11239-007-0157-y DB - PRIME DP - Unbound Medicine ER -