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Common and alternate oral antibiotic therapies for acne vulgaris: a review.
J Drugs Dermatol. 2007 Sep; 6(9):873-80.JD

Abstract

Acne vulgaris is an extremely common disorder affecting many adolescents and adults throughout their lifetimes. The pathogenesis of acne is multifactorial and is thought to involve excess sebum, follicular hyperkeratinization, bacterial colonization, and inflammation. Many therapeutic options exist for treating acne, including topical benzoyl peroxide, topical and oral antibiotics, topical and oral retinoids, and oral contraceptives. Oral antibiotics have been a mainstay in the treatment of acne for decades and function by exerting an antibacterial effect by reducing the follicular colonization of Propionibacterium acnes. Systemic antibiotics also have anti-inflammatory and immunomodulatory properties. This article reviews the English language literature on the efficacy of various systemic antibiotics for treating acne vulgaris, including second-line and less historically used medications. We discuss the tetracyclines, including subantimicrobial dose doxycycline, macrolides (notably azithromycin), trimethoprim-sulfamethoxazole, cephalosporins, and fluoroquinolones as treatment options for acne vulgaris.

Authors+Show Affiliations

Division of Dermatology, Department of Internal Medicine, KUMC, Kansas City, KS, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17941358

Citation

Amin, Kathani, et al. "Common and Alternate Oral Antibiotic Therapies for Acne Vulgaris: a Review." Journal of Drugs in Dermatology : JDD, vol. 6, no. 9, 2007, pp. 873-80.
Amin K, Riddle CC, Aires DJ, et al. Common and alternate oral antibiotic therapies for acne vulgaris: a review. J Drugs Dermatol. 2007;6(9):873-80.
Amin, K., Riddle, C. C., Aires, D. J., & Schweiger, E. S. (2007). Common and alternate oral antibiotic therapies for acne vulgaris: a review. Journal of Drugs in Dermatology : JDD, 6(9), 873-80.
Amin K, et al. Common and Alternate Oral Antibiotic Therapies for Acne Vulgaris: a Review. J Drugs Dermatol. 2007;6(9):873-80. PubMed PMID: 17941358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Common and alternate oral antibiotic therapies for acne vulgaris: a review. AU - Amin,Kathani, AU - Riddle,Christy C, AU - Aires,Daniel J, AU - Schweiger,Eric S, PY - 2007/10/19/pubmed PY - 2007/12/28/medline PY - 2007/10/19/entrez SP - 873 EP - 80 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 6 IS - 9 N2 - Acne vulgaris is an extremely common disorder affecting many adolescents and adults throughout their lifetimes. The pathogenesis of acne is multifactorial and is thought to involve excess sebum, follicular hyperkeratinization, bacterial colonization, and inflammation. Many therapeutic options exist for treating acne, including topical benzoyl peroxide, topical and oral antibiotics, topical and oral retinoids, and oral contraceptives. Oral antibiotics have been a mainstay in the treatment of acne for decades and function by exerting an antibacterial effect by reducing the follicular colonization of Propionibacterium acnes. Systemic antibiotics also have anti-inflammatory and immunomodulatory properties. This article reviews the English language literature on the efficacy of various systemic antibiotics for treating acne vulgaris, including second-line and less historically used medications. We discuss the tetracyclines, including subantimicrobial dose doxycycline, macrolides (notably azithromycin), trimethoprim-sulfamethoxazole, cephalosporins, and fluoroquinolones as treatment options for acne vulgaris. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/17941358/Common_and_alternate_oral_antibiotic_therapies_for_acne_vulgaris:_a_review_ L2 - https://medlineplus.gov/acne.html DB - PRIME DP - Unbound Medicine ER -