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Necrobiotic xanthogranuloma with paraproteinemia; an atypical case.
J Dtsch Dermatol Ges 2008; 6(1):40-3JD

Abstract

Necrobiotic xanthogranuloma (NXG) is a rare marker for paraproteinemia. An 86-year-old woman had a one year history of large red-yellow to brown annular plaques involving all limbs. Biopsies showed a non-palisading granuloma with numerous multinucleated giant cells showing prominent elastophagocytosis and extensive areas of necrobiosis throughout the entire dermis. Complete loss of elastic fibers was observed in the central atrophic area of an annular plaque. Small vascular thromboses were also present. Laboratory findings revealed paraproteinemia of IgG-lambda type. Immunohistochemical staining detected the presence of roughly equal numbers of IgG-lambda-and IgG-kappa-staining plasma cells in the dermis. We diagnosed NXG with paraproteinemia with monoclonal gammopathy (IgG-lambda type) of unknown significance.

Authors+Show Affiliations

Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng ger

PubMed ID

17941882

Citation

Ito, Yoshiyuki, et al. "Necrobiotic Xanthogranuloma With Paraproteinemia; an Atypical Case." Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, vol. 6, no. 1, 2008, pp. 40-3.
Ito Y, Nishimura K, Yamanaka K, et al. Necrobiotic xanthogranuloma with paraproteinemia; an atypical case. J Dtsch Dermatol Ges. 2008;6(1):40-3.
Ito, Y., Nishimura, K., Yamanaka, K., Hakamada, A., Isoda, K., Kurokawa, I., & Mizutani, H. (2008). Necrobiotic xanthogranuloma with paraproteinemia; an atypical case. Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 6(1), pp. 40-3.
Ito Y, et al. Necrobiotic Xanthogranuloma With Paraproteinemia; an Atypical Case. J Dtsch Dermatol Ges. 2008;6(1):40-3. PubMed PMID: 17941882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiotic xanthogranuloma with paraproteinemia; an atypical case. AU - Ito,Yoshiyuki, AU - Nishimura,Keisuke, AU - Yamanaka,Kei-Ichi, AU - Hakamada,Arata, AU - Isoda,Ken-Ichi, AU - Kurokawa,Ichiro, AU - Mizutani,Hitoshi, Y1 - 2007/10/18/ PY - 2007/10/19/pubmed PY - 2008/2/5/medline PY - 2007/10/19/entrez SP - 40 EP - 3 JF - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG JO - J Dtsch Dermatol Ges VL - 6 IS - 1 N2 - Necrobiotic xanthogranuloma (NXG) is a rare marker for paraproteinemia. An 86-year-old woman had a one year history of large red-yellow to brown annular plaques involving all limbs. Biopsies showed a non-palisading granuloma with numerous multinucleated giant cells showing prominent elastophagocytosis and extensive areas of necrobiosis throughout the entire dermis. Complete loss of elastic fibers was observed in the central atrophic area of an annular plaque. Small vascular thromboses were also present. Laboratory findings revealed paraproteinemia of IgG-lambda type. Immunohistochemical staining detected the presence of roughly equal numbers of IgG-lambda-and IgG-kappa-staining plasma cells in the dermis. We diagnosed NXG with paraproteinemia with monoclonal gammopathy (IgG-lambda type) of unknown significance. SN - 1610-0387 UR - https://www.unboundmedicine.com/medline/citation/17941882/Necrobiotic_xanthogranuloma_with_paraproteinemia L2 - https://doi.org/10.1111/j.1610-0387.2007.06392.x DB - PRIME DP - Unbound Medicine ER -