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Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects.
Clin Exp Pharmacol Physiol. 2008 Feb; 35(2):187-91.CE

Abstract

1. The aim of the present study was to determine whether the peroxisome proliferator-activated receptor (PPAR)-g Pro12Ala polymorphism affects susceptibility to diabetes in Uygur, Kazak and Han subjects in Xinjiang, China. 2. Uygur, Kazak and Han subjects from Kashi, Yili and Shawan (Xinjiang, China) were enrolled in the present study. The PPAR-g Pro12Ala polymorphism was determined using restriction fragment length polymorphism. Anthropometric and serum biological indices were monitored among different genotype carriers to examine the PPAR-g Pro12Ala gene polymorphism and the prevalence of type 2 diabetes. 3. The distribution frequency of the Pro12Ala genotype did not differ between diabetic and non-diabetic Uygur, Kazak and Han subjects. However, the frequency of the A allele of Pro12Ala was significant different among non-diabetics, with frequencies of 11, 9 and 5% in Uygur, Kazak and Han groups, respectively. Using the c(2) test, it was shown that the frequency of the A allele in Uygurs (11%) was significantly higher than that in Han subjects (5%). To compare the wild-type (Pro/Pro) carriers in diabetics from each ethnic group, Ugyur subjects, who carry PPAR-g Pro12Ala (Pro/Ala), had a larger waist circumference and lower low-density lipoprotein-cholesterol level, Kazaks subjects showed larger waist circumference and higher high-density lipoprotein levels and Han subjects exhibited a high waist-to-hip ratio and body mass index. 4. The present study revealed that the allele and genotype frequency did not differ in diabetics and non-diabetics of each ethnic group. However, the frequency of the A allele was significantly different in non-diabetics from various ethnic groups. These data suggest that PPAR-g Pro12Ala may affect blood lipid levels and the abdominal fat storage of diabetic Ugyurs and Kazaks and may be associated with fat storage and insulin resistance in Hans.

Authors+Show Affiliations

Department of Pharmacology, Xinjiang Medical University, Urumuqi, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17941898

Citation

Li, Lin-Lin, et al. "Genetic Polymorphism of Peroxisome Proliferator-activated Receptor-gamma 2 Pro12Ala On Ethnic Susceptibility to Diabetes in Uygur, Kazak and Han Subjects." Clinical and Experimental Pharmacology & Physiology, vol. 35, no. 2, 2008, pp. 187-91.
Li LL, Ma XL, Ran JX, et al. Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects. Clin Exp Pharmacol Physiol. 2008;35(2):187-91.
Li, L. L., Ma, X. L., Ran, J. X., Sun, X. F., Xu, L. M., Ren, J., & Mao, X. M. (2008). Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects. Clinical and Experimental Pharmacology & Physiology, 35(2), 187-91.
Li LL, et al. Genetic Polymorphism of Peroxisome Proliferator-activated Receptor-gamma 2 Pro12Ala On Ethnic Susceptibility to Diabetes in Uygur, Kazak and Han Subjects. Clin Exp Pharmacol Physiol. 2008;35(2):187-91. PubMed PMID: 17941898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects. AU - Li,Lin-Lin, AU - Ma,Xiao-Li, AU - Ran,Jian-Xin, AU - Sun,Xiao-Feng, AU - Xu,Li-Ming, AU - Ren,Jun, AU - Mao,Xin-Min, Y1 - 2007/10/17/ PY - 2007/10/19/pubmed PY - 2008/2/1/medline PY - 2007/10/19/entrez SP - 187 EP - 91 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 35 IS - 2 N2 - 1. The aim of the present study was to determine whether the peroxisome proliferator-activated receptor (PPAR)-g Pro12Ala polymorphism affects susceptibility to diabetes in Uygur, Kazak and Han subjects in Xinjiang, China. 2. Uygur, Kazak and Han subjects from Kashi, Yili and Shawan (Xinjiang, China) were enrolled in the present study. The PPAR-g Pro12Ala polymorphism was determined using restriction fragment length polymorphism. Anthropometric and serum biological indices were monitored among different genotype carriers to examine the PPAR-g Pro12Ala gene polymorphism and the prevalence of type 2 diabetes. 3. The distribution frequency of the Pro12Ala genotype did not differ between diabetic and non-diabetic Uygur, Kazak and Han subjects. However, the frequency of the A allele of Pro12Ala was significant different among non-diabetics, with frequencies of 11, 9 and 5% in Uygur, Kazak and Han groups, respectively. Using the c(2) test, it was shown that the frequency of the A allele in Uygurs (11%) was significantly higher than that in Han subjects (5%). To compare the wild-type (Pro/Pro) carriers in diabetics from each ethnic group, Ugyur subjects, who carry PPAR-g Pro12Ala (Pro/Ala), had a larger waist circumference and lower low-density lipoprotein-cholesterol level, Kazaks subjects showed larger waist circumference and higher high-density lipoprotein levels and Han subjects exhibited a high waist-to-hip ratio and body mass index. 4. The present study revealed that the allele and genotype frequency did not differ in diabetics and non-diabetics of each ethnic group. However, the frequency of the A allele was significantly different in non-diabetics from various ethnic groups. These data suggest that PPAR-g Pro12Ala may affect blood lipid levels and the abdominal fat storage of diabetic Ugyurs and Kazaks and may be associated with fat storage and insulin resistance in Hans. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/17941898/Genetic_polymorphism_of_peroxisome_proliferator_activated_receptor_gamma_2_Pro12Ala_on_ethnic_susceptibility_to_diabetes_in_Uygur_Kazak_and_Han_subjects_ L2 - https://doi.org/10.1111/j.1440-1681.2007.04796.x DB - PRIME DP - Unbound Medicine ER -