Tags

Type your tag names separated by a space and hit enter

The outcome of patients with pathological Gleason score >or=8 prostate cancer after radical prostatectomy.
BJU Int. 2008 Feb; 101(3):305-7.BI

Abstract

OBJECTIVE

To analyse the outcome of patients undergoing radical prostatectomy (RP) for Gleason 8-10 clinically localized prostate cancer, and to evaluate the prognostic value of well-known predictors of progression.

PATIENTS AND METHODS

In all, 1480 patients had RP between 1988 and 2006, of whom 180 had pathological Gleason score >or=8 and negative lymph nodes. Biochemical progression-free survival was determined using the Kaplan-Meier method. The effect of preoperative prostate-specific antigen (PSA) level, pathological stage and margin status was assessed with univariate and multivariate analyses.

RESULTS

Of the 180 patients, the Gleason score in the RP specimen was 8, 9 or 10 in 70%, 27% and 3%, respectively; 24% had stage pT2 disease, 30% stage pT3a, 25% stage pT3b and 20% stage pT4a. The 5- and 7-year biochemical progression-free survival was 73 and 65% for stage pT2, 40% and 27% for stage pT3a, and 30% for stage pT3b (log rank test, P < 0.001). In the univariate model, preoperative PSA level, pathological stage and surgical margins were predictors of survival. In the multivariate analysis, preoperative PSA level and extracapsular extension predicted biochemical progression-free survival.

CONCLUSION

Gleason 8-10 tumours have a poor prognosis. Patients with a PSA level of <10 ng/mL and stage pT2 disease have the greatest likelihood of having a longer progression-free survival after RP.

Authors+Show Affiliations

Department of Urology, Henri Mondor Universtity Hospital, Créteil, France. ftrc5@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17941921

Citation

Rodriguez-Covarrubias, Francisco, et al. "The Outcome of Patients With Pathological Gleason Score >or=8 Prostate Cancer After Radical Prostatectomy." BJU International, vol. 101, no. 3, 2008, pp. 305-7.
Rodriguez-Covarrubias F, Larre S, De La Taille A, et al. The outcome of patients with pathological Gleason score >or=8 prostate cancer after radical prostatectomy. BJU Int. 2008;101(3):305-7.
Rodriguez-Covarrubias, F., Larre, S., De La Taille, A., Abbou, C. C., & Salomon, L. (2008). The outcome of patients with pathological Gleason score >or=8 prostate cancer after radical prostatectomy. BJU International, 101(3), 305-7.
Rodriguez-Covarrubias F, et al. The Outcome of Patients With Pathological Gleason Score >or=8 Prostate Cancer After Radical Prostatectomy. BJU Int. 2008;101(3):305-7. PubMed PMID: 17941921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The outcome of patients with pathological Gleason score >or=8 prostate cancer after radical prostatectomy. AU - Rodriguez-Covarrubias,Francisco, AU - Larre,Stephane, AU - De La Taille,Alexandre, AU - Abbou,Claude-Clement, AU - Salomon,Laurent, Y1 - 2007/10/17/ PY - 2007/10/19/pubmed PY - 2008/2/9/medline PY - 2007/10/19/entrez SP - 305 EP - 7 JF - BJU international JO - BJU Int VL - 101 IS - 3 N2 - OBJECTIVE: To analyse the outcome of patients undergoing radical prostatectomy (RP) for Gleason 8-10 clinically localized prostate cancer, and to evaluate the prognostic value of well-known predictors of progression. PATIENTS AND METHODS: In all, 1480 patients had RP between 1988 and 2006, of whom 180 had pathological Gleason score >or=8 and negative lymph nodes. Biochemical progression-free survival was determined using the Kaplan-Meier method. The effect of preoperative prostate-specific antigen (PSA) level, pathological stage and margin status was assessed with univariate and multivariate analyses. RESULTS: Of the 180 patients, the Gleason score in the RP specimen was 8, 9 or 10 in 70%, 27% and 3%, respectively; 24% had stage pT2 disease, 30% stage pT3a, 25% stage pT3b and 20% stage pT4a. The 5- and 7-year biochemical progression-free survival was 73 and 65% for stage pT2, 40% and 27% for stage pT3a, and 30% for stage pT3b (log rank test, P < 0.001). In the univariate model, preoperative PSA level, pathological stage and surgical margins were predictors of survival. In the multivariate analysis, preoperative PSA level and extracapsular extension predicted biochemical progression-free survival. CONCLUSION: Gleason 8-10 tumours have a poor prognosis. Patients with a PSA level of <10 ng/mL and stage pT2 disease have the greatest likelihood of having a longer progression-free survival after RP. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/17941921/The_outcome_of_patients_with_pathological_Gleason_score_>or=8_prostate_cancer_after_radical_prostatectomy_ L2 - https://doi.org/10.1111/j.1464-410X.2007.07273.x DB - PRIME DP - Unbound Medicine ER -