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Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease.
J Neurol Sci. 2008 Mar 15; 266(1-2):145-9.JN

Abstract

In a case-control study involving 400 study subjects, we found a higher prevalence of restless legs syndrome (RLS) in our Parkinson's disease (PD) patients compared to controls (3.0% vs 0.5%) (odds ratio 6.2) (p=0.07). Polysomnographic studies confirmed that study subjects with RLS had grossly elevated PLMS index, PLMS arousal index and reduced sleep efficiency. None of these PD patients reported a family history of PD or RLS. The average age of onset of RLS was 61.7+/-10.8 years old. The mean global Pittsburgh Sleep Quality Index (PSQI) score of PD patients was significantly higher than the controls (9.1+/-4.5 vs 4.3+/-2.8, p<0.0001). All the seven components of PSQI in PD patients were significantly different from controls (p<0.0001). Multivariate analysis revealed that only Hoehn and Yahr staging correlated with the global PSQI score (p<0.0001). Similar results were obtained when we compared the PSQI score between PD patients without RLS with controls. Our case-control study demonstrated a weak association between RLS and PD. PD patients have significant poor quality of sleep, and this correlated with the severity of PD. RLS did not play an important role in sleep dysfunction in our PD cohort. A high index of suspicion for sleep problems in advanced PD patients is important as early management could improve their quality of life.

Authors+Show Affiliations

Department of Neurology, Singapore General Hospital National Neuroscience Institute SingHealth, Singapore.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17942122

Citation

Loo, Hui-Voon, and Eng-King Tan. "Case-control Study of Restless Legs Syndrome and Quality of Sleep in Parkinson's Disease." Journal of the Neurological Sciences, vol. 266, no. 1-2, 2008, pp. 145-9.
Loo HV, Tan EK. Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease. J Neurol Sci. 2008;266(1-2):145-9.
Loo, H. V., & Tan, E. K. (2008). Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease. Journal of the Neurological Sciences, 266(1-2), 145-9.
Loo HV, Tan EK. Case-control Study of Restless Legs Syndrome and Quality of Sleep in Parkinson's Disease. J Neurol Sci. 2008 Mar 15;266(1-2):145-9. PubMed PMID: 17942122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease. AU - Loo,Hui-Voon, AU - Tan,Eng-King, Y1 - 2007/10/17/ PY - 2007/04/02/received PY - 2007/07/29/revised PY - 2007/09/14/accepted PY - 2007/10/19/pubmed PY - 2008/4/29/medline PY - 2007/10/19/entrez SP - 145 EP - 9 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 266 IS - 1-2 N2 - In a case-control study involving 400 study subjects, we found a higher prevalence of restless legs syndrome (RLS) in our Parkinson's disease (PD) patients compared to controls (3.0% vs 0.5%) (odds ratio 6.2) (p=0.07). Polysomnographic studies confirmed that study subjects with RLS had grossly elevated PLMS index, PLMS arousal index and reduced sleep efficiency. None of these PD patients reported a family history of PD or RLS. The average age of onset of RLS was 61.7+/-10.8 years old. The mean global Pittsburgh Sleep Quality Index (PSQI) score of PD patients was significantly higher than the controls (9.1+/-4.5 vs 4.3+/-2.8, p<0.0001). All the seven components of PSQI in PD patients were significantly different from controls (p<0.0001). Multivariate analysis revealed that only Hoehn and Yahr staging correlated with the global PSQI score (p<0.0001). Similar results were obtained when we compared the PSQI score between PD patients without RLS with controls. Our case-control study demonstrated a weak association between RLS and PD. PD patients have significant poor quality of sleep, and this correlated with the severity of PD. RLS did not play an important role in sleep dysfunction in our PD cohort. A high index of suspicion for sleep problems in advanced PD patients is important as early management could improve their quality of life. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17942122/Case_control_study_of_restless_legs_syndrome_and_quality_of_sleep_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00646-6 DB - PRIME DP - Unbound Medicine ER -