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Risk factors for meticillin resistance and outcome of Staphylococcus aureus bloodstream infection in a Belgian university hospital.
J Hosp Infect 2008; 68(1):17-24JH

Abstract

The aim of this study was to identify institution-specific risk factors for meticillin resistance in Staphylococcus aureus bloodstream infection (BSI) and to evaluate the impact of meticillin resistance on mortality. A total of 154 episodes of S. aureus BSI were identified between 1 January 2002 and 31 December 2004: 66 meticillin-resistant S. aureus (MRSA) BSI and 88 meticillin-susceptible S. aureus (MSSA) BSI. Seventy-eight episodes (51%) were considered to be community-acquired and 76 (49%) as nosocomial. Risk factors associated with MRSA BSI included not living at home (P=0.001), prior antibiotic exposure (P=0.002), insulin-requiring diabetes (P=0.028) and nosocomial BSI (P=0.031), especially more than 12.5 days after admission. There was an association between BSI-related mortality and the following variables: septic shock (P<0.001), endocarditis (P=0.002) and MRSA BSI (P=0.021). In conclusion, S. aureus BSI is a serious condition, especially when septic shock or endocarditis occurs, and is aggravated by meticillin resistance. We advise glycopeptides as empirical therapy for patients not arriving from home, those exposed to antibiotics, and those with insulin-requiring diabetes and/or nosocomial BSI.

Authors+Show Affiliations

Brugmann University Hospital, Brussels, Belgium. maryse.libert@chu-brugmann.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17942190

Citation

Libert, M, et al. "Risk Factors for Meticillin Resistance and Outcome of Staphylococcus Aureus Bloodstream Infection in a Belgian University Hospital." The Journal of Hospital Infection, vol. 68, no. 1, 2008, pp. 17-24.
Libert M, Elkholti M, Massaut J, et al. Risk factors for meticillin resistance and outcome of Staphylococcus aureus bloodstream infection in a Belgian university hospital. J Hosp Infect. 2008;68(1):17-24.
Libert, M., Elkholti, M., Massaut, J., Karmali, R., Mascart, G., & Cherifi, S. (2008). Risk factors for meticillin resistance and outcome of Staphylococcus aureus bloodstream infection in a Belgian university hospital. The Journal of Hospital Infection, 68(1), pp. 17-24.
Libert M, et al. Risk Factors for Meticillin Resistance and Outcome of Staphylococcus Aureus Bloodstream Infection in a Belgian University Hospital. J Hosp Infect. 2008;68(1):17-24. PubMed PMID: 17942190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for meticillin resistance and outcome of Staphylococcus aureus bloodstream infection in a Belgian university hospital. AU - Libert,M, AU - Elkholti,M, AU - Massaut,J, AU - Karmali,R, AU - Mascart,G, AU - Cherifi,S, Y1 - 2007/10/22/ PY - 2007/03/05/received PY - 2007/08/24/accepted PY - 2007/10/19/pubmed PY - 2008/3/26/medline PY - 2007/10/19/entrez SP - 17 EP - 24 JF - The Journal of hospital infection JO - J. Hosp. Infect. VL - 68 IS - 1 N2 - The aim of this study was to identify institution-specific risk factors for meticillin resistance in Staphylococcus aureus bloodstream infection (BSI) and to evaluate the impact of meticillin resistance on mortality. A total of 154 episodes of S. aureus BSI were identified between 1 January 2002 and 31 December 2004: 66 meticillin-resistant S. aureus (MRSA) BSI and 88 meticillin-susceptible S. aureus (MSSA) BSI. Seventy-eight episodes (51%) were considered to be community-acquired and 76 (49%) as nosocomial. Risk factors associated with MRSA BSI included not living at home (P=0.001), prior antibiotic exposure (P=0.002), insulin-requiring diabetes (P=0.028) and nosocomial BSI (P=0.031), especially more than 12.5 days after admission. There was an association between BSI-related mortality and the following variables: septic shock (P<0.001), endocarditis (P=0.002) and MRSA BSI (P=0.021). In conclusion, S. aureus BSI is a serious condition, especially when septic shock or endocarditis occurs, and is aggravated by meticillin resistance. We advise glycopeptides as empirical therapy for patients not arriving from home, those exposed to antibiotics, and those with insulin-requiring diabetes and/or nosocomial BSI. SN - 0195-6701 UR - https://www.unboundmedicine.com/medline/citation/17942190/Risk_factors_for_meticillin_resistance_and_outcome_of_Staphylococcus_aureus_bloodstream_infection_in_a_Belgian_university_hospital_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(07)00306-4 DB - PRIME DP - Unbound Medicine ER -