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The red cell distribution width in sickle cell disease--is it of clinical value?
Clin Lab Haematol. 1991; 13(3):229-37.CL

Abstract

The red cell distribution width (RDW) has been studied during the clinical steady state in 1121 patients with homozygous sickle cell (SS) disease, 344 with sickle cell-haemoglobin C (SC) disease, 68 with sickle cell-beta+ thalassaemia, 49 with sickle cell beta 0 thalassaemia and in 130 control subjects with a normal (AA) genotype. The mean RDW was moderately increased in S beta + thalassaemia and SC disease and markedly increased in S beta 0 thalassaemia and SS disease. In SS, SC and S beta 0 thalassaemia genotypes, lower RDW values occurred in females and with alpha thalassaemia. The RDW correlated negatively with total haemoglobin, mean cell haemoglobin concentration, mean cell volume, and fetal haemoglobin (HbF) and positively with reticulocyte count in SS disease. A low RDW was associated with higher weight and less frequent dactylitis, painful crisis, acute chest syndrome, acute splenic sequestration, and hospital admissions. A low RDW in SS disease is consistent with a high total haemoglobin, high HbF, low reticulocyte count, alpha thalassaemia, and a more mild clinical course.

Authors+Show Affiliations

Department of Child Health, University of the West Indies, Mona, Kingston Jamaica.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1794225

Citation

Thame, M, et al. "The Red Cell Distribution Width in Sickle Cell Disease--is It of Clinical Value?" Clinical and Laboratory Haematology, vol. 13, no. 3, 1991, pp. 229-37.
Thame M, Grandison Y, Mason K, et al. The red cell distribution width in sickle cell disease--is it of clinical value? Clin Lab Haematol. 1991;13(3):229-37.
Thame, M., Grandison, Y., Mason, K., Thompson, M., Higgs, D., Morris, J., Serjeant, B., & Serjeant, G. (1991). The red cell distribution width in sickle cell disease--is it of clinical value? Clinical and Laboratory Haematology, 13(3), 229-37.
Thame M, et al. The Red Cell Distribution Width in Sickle Cell Disease--is It of Clinical Value. Clin Lab Haematol. 1991;13(3):229-37. PubMed PMID: 1794225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The red cell distribution width in sickle cell disease--is it of clinical value? AU - Thame,M, AU - Grandison,Y, AU - Mason,K, AU - Thompson,M, AU - Higgs,D, AU - Morris,J, AU - Serjeant,B, AU - Serjeant,G, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 229 EP - 37 JF - Clinical and laboratory haematology JO - Clin Lab Haematol VL - 13 IS - 3 N2 - The red cell distribution width (RDW) has been studied during the clinical steady state in 1121 patients with homozygous sickle cell (SS) disease, 344 with sickle cell-haemoglobin C (SC) disease, 68 with sickle cell-beta+ thalassaemia, 49 with sickle cell beta 0 thalassaemia and in 130 control subjects with a normal (AA) genotype. The mean RDW was moderately increased in S beta + thalassaemia and SC disease and markedly increased in S beta 0 thalassaemia and SS disease. In SS, SC and S beta 0 thalassaemia genotypes, lower RDW values occurred in females and with alpha thalassaemia. The RDW correlated negatively with total haemoglobin, mean cell haemoglobin concentration, mean cell volume, and fetal haemoglobin (HbF) and positively with reticulocyte count in SS disease. A low RDW was associated with higher weight and less frequent dactylitis, painful crisis, acute chest syndrome, acute splenic sequestration, and hospital admissions. A low RDW in SS disease is consistent with a high total haemoglobin, high HbF, low reticulocyte count, alpha thalassaemia, and a more mild clinical course. SN - 0141-9854 UR - https://www.unboundmedicine.com/medline/citation/1794225/The_red_cell_distribution_width_in_sickle_cell_disease__is_it_of_clinical_value L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9854&date=1991&volume=13&issue=3&spage=229 DB - PRIME DP - Unbound Medicine ER -