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Insulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts.
Psychosom Med. 2007 Nov; 69(8):723-8.PM

Abstract

OBJECTIVE

To investigate whether the association between insulin resistance (IR) and depressive symptoms is present already in young adult males. The association between IR and depression has been poorly studied, although the existence of a connection of Type II diabetes with depression is well established. We previously demonstrated at epidemiological level in two groups of men aged 31 years and 61 to 63 years that IR is linked with depressive symptoms.

METHODS

In a cross-sectional study, involving 1054 healthy Finnish male military conscripts of about 19 years of age, IR was defined through homeostasis model assessment (HOMA-IR). The severity of the depressive symptoms was evaluated through a Finnish modification of the 13-item Beck Depression Inventory (R-BDI). Moderate-to-severe depressive symptoms were said to be present, if the R-BDI score was > or = 8, and mild depressive symptoms were present if the R-BDI score was 5 to 7.

RESULTS

After adjusting for confounders, moderate-to-severe depressive symptoms increased the risk for IR, as defined by the highest decile of the HOMA-IR, up to 2.8-fold (odds ratio = 2.8; 1.2-6.5). Mild depressive symptoms were not significantly associated with IR.

CONCLUSIONS

In young adult males, co-occurring strictly defined IR seems to be positively associated with current moderate-to-severe depressive symptoms.

Authors+Show Affiliations

Department of Public Health Science and General Practice, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland. markku.timonen@oulu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17942838

Citation

Timonen, Markku, et al. "Insulin Resistance and Depressive Symptoms in Young Adult Males: Findings From Finnish Military Conscripts." Psychosomatic Medicine, vol. 69, no. 8, 2007, pp. 723-8.
Timonen M, Salmenkaita I, Jokelainen J, et al. Insulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts. Psychosom Med. 2007;69(8):723-8.
Timonen, M., Salmenkaita, I., Jokelainen, J., Laakso, M., Härkönen, P., Koskela, P., Meyer-Rochow, V. B., Peitso, A., & Keinänen-Kiukaanniemi, S. (2007). Insulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts. Psychosomatic Medicine, 69(8), 723-8.
Timonen M, et al. Insulin Resistance and Depressive Symptoms in Young Adult Males: Findings From Finnish Military Conscripts. Psychosom Med. 2007;69(8):723-8. PubMed PMID: 17942838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts. AU - Timonen,Markku, AU - Salmenkaita,Ilkka, AU - Jokelainen,Jari, AU - Laakso,Mauri, AU - Härkönen,Pirjo, AU - Koskela,Pentti, AU - Meyer-Rochow,V Benno, AU - Peitso,Ari, AU - Keinänen-Kiukaanniemi,Sirkka, Y1 - 2007/10/17/ PY - 2007/10/19/pubmed PY - 2007/12/11/medline PY - 2007/10/19/entrez SP - 723 EP - 8 JF - Psychosomatic medicine JO - Psychosom Med VL - 69 IS - 8 N2 - OBJECTIVE: To investigate whether the association between insulin resistance (IR) and depressive symptoms is present already in young adult males. The association between IR and depression has been poorly studied, although the existence of a connection of Type II diabetes with depression is well established. We previously demonstrated at epidemiological level in two groups of men aged 31 years and 61 to 63 years that IR is linked with depressive symptoms. METHODS: In a cross-sectional study, involving 1054 healthy Finnish male military conscripts of about 19 years of age, IR was defined through homeostasis model assessment (HOMA-IR). The severity of the depressive symptoms was evaluated through a Finnish modification of the 13-item Beck Depression Inventory (R-BDI). Moderate-to-severe depressive symptoms were said to be present, if the R-BDI score was > or = 8, and mild depressive symptoms were present if the R-BDI score was 5 to 7. RESULTS: After adjusting for confounders, moderate-to-severe depressive symptoms increased the risk for IR, as defined by the highest decile of the HOMA-IR, up to 2.8-fold (odds ratio = 2.8; 1.2-6.5). Mild depressive symptoms were not significantly associated with IR. CONCLUSIONS: In young adult males, co-occurring strictly defined IR seems to be positively associated with current moderate-to-severe depressive symptoms. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/17942838/Insulin_resistance_and_depressive_symptoms_in_young_adult_males:_findings_from_Finnish_military_conscripts_ L2 - https://doi.org/10.1097/PSY.0b013e318157ad2e DB - PRIME DP - Unbound Medicine ER -