Tags

Type your tag names separated by a space and hit enter

Increased saliva cortisol awakening response in patients with mild cognitive impairment.
Dement Geriatr Cogn Disord. 2007; 24(5):389-95.DG

Abstract

BACKGROUND

It is unknown whether HPA-axis dysfunction is present in patients with mild cognitive impairment (MCI). The aim of the present study was to investigate whether cortisol levels are elevated among patients with MCI and/or whether the individuals have adequate feedback control of their HPA axis.

MATERIAL AND METHODS

27 patients with MCI and 15 healthy controls were included in the study. Saliva samplings were performed 5 times a day before intake of 0.5 mg dexamethasone, and 5 times a day after intake of dexamethasone, respectively.

RESULTS

Significantly higher cortisol levels were found 15 min after awakening among patients with MCI in comparison with the controls, both before and after dexamethasone administration (p<0.05). Also, the ratio between cortisol at awakening time and 15 min after awakening was lower in the patient group after dexamethasone administration (p<0.05). There were no significant differences in basal cortisol levels before or after dexamethasone between groups.

CONCLUSION

The results indicate that there is an HPA-axis disturbance, with normal basal cortisol levels and increased awakening response among patients with MCI. The dissociation between basal values and the awakening response may be of pathophysiological importance for the cognitive impairment.

Authors+Show Affiliations

Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Mölndal, Sweden. karin.lind@neuro.gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17943022

Citation

Lind, Karin, et al. "Increased Saliva Cortisol Awakening Response in Patients With Mild Cognitive Impairment." Dementia and Geriatric Cognitive Disorders, vol. 24, no. 5, 2007, pp. 389-95.
Lind K, Edman A, Nordlund A, et al. Increased saliva cortisol awakening response in patients with mild cognitive impairment. Dement Geriatr Cogn Disord. 2007;24(5):389-95.
Lind, K., Edman, A., Nordlund, A., Olsson, T., & Wallin, A. (2007). Increased saliva cortisol awakening response in patients with mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 24(5), 389-95.
Lind K, et al. Increased Saliva Cortisol Awakening Response in Patients With Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 2007;24(5):389-95. PubMed PMID: 17943022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased saliva cortisol awakening response in patients with mild cognitive impairment. AU - Lind,Karin, AU - Edman,Ake, AU - Nordlund,Arto, AU - Olsson,Tommy, AU - Wallin,Anders, Y1 - 2007/10/17/ PY - 2007/02/27/accepted PY - 2007/10/19/pubmed PY - 2008/1/11/medline PY - 2007/10/19/entrez SP - 389 EP - 95 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 24 IS - 5 N2 - BACKGROUND: It is unknown whether HPA-axis dysfunction is present in patients with mild cognitive impairment (MCI). The aim of the present study was to investigate whether cortisol levels are elevated among patients with MCI and/or whether the individuals have adequate feedback control of their HPA axis. MATERIAL AND METHODS: 27 patients with MCI and 15 healthy controls were included in the study. Saliva samplings were performed 5 times a day before intake of 0.5 mg dexamethasone, and 5 times a day after intake of dexamethasone, respectively. RESULTS: Significantly higher cortisol levels were found 15 min after awakening among patients with MCI in comparison with the controls, both before and after dexamethasone administration (p<0.05). Also, the ratio between cortisol at awakening time and 15 min after awakening was lower in the patient group after dexamethasone administration (p<0.05). There were no significant differences in basal cortisol levels before or after dexamethasone between groups. CONCLUSION: The results indicate that there is an HPA-axis disturbance, with normal basal cortisol levels and increased awakening response among patients with MCI. The dissociation between basal values and the awakening response may be of pathophysiological importance for the cognitive impairment. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17943022/Increased_saliva_cortisol_awakening_response_in_patients_with_mild_cognitive_impairment_ L2 - https://www.karger.com?DOI=10.1159/000109938 DB - PRIME DP - Unbound Medicine ER -