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FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns.
Genes Chromosomes Cancer. 2008 Jan; 47(1):64-70.GC

Abstract

During 1995-2004, 209 children/adolescents were diagnosed with acute lymphoblastic or myeloid leukemia (ALL, AML) in Southern Sweden, of which 177 (85%), comprising 128 B-lineage ALL, 34 AML, and 15 T-cell ALL, could be analyzed for internal tandem duplications (ITD) and activating point mutations in the second tyrosine kinase domain (ATKD) of FLT3. Seventeen (10%) FLT3 mutations (6 ITD, 11 ATKD; mutually exclusive) were detected. None of the T-cell ALL harbored any mutations. ITD and ATKD were found in 2% and 6% of the B-lineage ALL and in 12% and 9% of the AML, being particularly common in high hyperdiploid ALL (14%), ALL (20%), and AML (23%) with 11q23/MLL rearrangements, and in AML with a normal karyotype (60%). All ATKD-positive AML with MLL rearrangements harbored the t(9;11)(p21;q23). Global gene expression data were available for 76 of the B-lineage ALL and 19 of the AML, of which 6 (8%) and 3 (16%) had FLT3 mutations, respectively. No distinct expression pattern associated with FLT3 mutations was identified.

Authors+Show Affiliations

Department of Clinical Genetics, University Hospital, Lund, Sweden. anna.andersson@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17943971

Citation

Andersson, Anna, et al. "FLT3 Mutations in a 10 Year Consecutive Series of 177 Childhood Acute Leukemias and Their Impact On Global Gene Expression Patterns." Genes, Chromosomes & Cancer, vol. 47, no. 1, 2008, pp. 64-70.
Andersson A, Paulsson K, Lilljebjörn H, et al. FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. Genes Chromosomes Cancer. 2008;47(1):64-70.
Andersson, A., Paulsson, K., Lilljebjörn, H., Lassen, C., Strömbeck, B., Heldrup, J., Behrendtz, M., Johansson, B., & Fioretos, T. (2008). FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. Genes, Chromosomes & Cancer, 47(1), 64-70.
Andersson A, et al. FLT3 Mutations in a 10 Year Consecutive Series of 177 Childhood Acute Leukemias and Their Impact On Global Gene Expression Patterns. Genes Chromosomes Cancer. 2008;47(1):64-70. PubMed PMID: 17943971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. AU - Andersson,Anna, AU - Paulsson,Kajsa, AU - Lilljebjörn,Henrik, AU - Lassen,Carin, AU - Strömbeck,Bodil, AU - Heldrup,Jesper, AU - Behrendtz,Mikael, AU - Johansson,Bertil, AU - Fioretos,Thoas, PY - 2007/10/19/pubmed PY - 2008/2/6/medline PY - 2007/10/19/entrez SP - 64 EP - 70 JF - Genes, chromosomes & cancer JO - Genes Chromosomes Cancer VL - 47 IS - 1 N2 - During 1995-2004, 209 children/adolescents were diagnosed with acute lymphoblastic or myeloid leukemia (ALL, AML) in Southern Sweden, of which 177 (85%), comprising 128 B-lineage ALL, 34 AML, and 15 T-cell ALL, could be analyzed for internal tandem duplications (ITD) and activating point mutations in the second tyrosine kinase domain (ATKD) of FLT3. Seventeen (10%) FLT3 mutations (6 ITD, 11 ATKD; mutually exclusive) were detected. None of the T-cell ALL harbored any mutations. ITD and ATKD were found in 2% and 6% of the B-lineage ALL and in 12% and 9% of the AML, being particularly common in high hyperdiploid ALL (14%), ALL (20%), and AML (23%) with 11q23/MLL rearrangements, and in AML with a normal karyotype (60%). All ATKD-positive AML with MLL rearrangements harbored the t(9;11)(p21;q23). Global gene expression data were available for 76 of the B-lineage ALL and 19 of the AML, of which 6 (8%) and 3 (16%) had FLT3 mutations, respectively. No distinct expression pattern associated with FLT3 mutations was identified. SN - 1045-2257 UR - https://www.unboundmedicine.com/medline/citation/17943971/FLT3_mutations_in_a_10_year_consecutive_series_of_177_childhood_acute_leukemias_and_their_impact_on_global_gene_expression_patterns_ L2 - https://doi.org/10.1002/gcc.20508 DB - PRIME DP - Unbound Medicine ER -