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Neuraminidase inhibitors and their role in avian and pandemic influenza.

Abstract

Continuing occurrences of human infections with avian influenza A (H5N1) viruses have ignited increasing fears that the next influenza pandemic is imminent. Fortunately, options for antiviral prophylaxis and treatment have been improved dramatically since the previous pandemics by the availability of neuraminidase inhibitors such as zanamivir and oseltamivir. However, although the prophylactic and therapeutic efficacy of these drugs is well established for uncomplicated seasonal human influenza, clinical effectiveness seems limited for human H5N1 infections despite in vitro susceptibility and efficacy in animal studies. Factors which might contribute to this apparently limited efficacy include suboptimal dosing or routes of administration, suboptimal timing of treatment and the inability of antiviral drugs to interfere with immunopathology, and the development of drug resistance. Efforts to optimize the use of neuraminidase inhibitor treatment in H5N1 disease are urgently needed and might eventually aid in the judicious use of stockpiled neuraminidase inhibitors in the event of a pandemic.

Authors+Show Affiliations

,

Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Source

Antiviral therapy 12:4 Pt B 2007 pg 593-602

MeSH

Animals
Antiviral Agents
Birds
Disease Outbreaks
Drug Resistance, Viral
Enzyme Inhibitors
Humans
Influenza A Virus, H5N1 Subtype
Influenza A Virus, H9N2 Subtype
Influenza in Birds
Influenza, Human
Mice
Neuraminidase
Oseltamivir
Zanamivir

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17944267

Citation

Crusat, Martin, and Menno D. de Jong. "Neuraminidase Inhibitors and Their Role in Avian and Pandemic Influenza." Antiviral Therapy, vol. 12, no. 4 Pt B, 2007, pp. 593-602.
Crusat M, de Jong MD. Neuraminidase inhibitors and their role in avian and pandemic influenza. Antivir Ther (Lond). 2007;12(4 Pt B):593-602.
Crusat, M., & de Jong, M. D. (2007). Neuraminidase inhibitors and their role in avian and pandemic influenza. Antiviral Therapy, 12(4 Pt B), pp. 593-602.
Crusat M, de Jong MD. Neuraminidase Inhibitors and Their Role in Avian and Pandemic Influenza. Antivir Ther (Lond). 2007;12(4 Pt B):593-602. PubMed PMID: 17944267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuraminidase inhibitors and their role in avian and pandemic influenza. AU - Crusat,Martin, AU - de Jong,Menno D, PY - 2007/10/20/pubmed PY - 2007/11/2/medline PY - 2007/10/20/entrez SP - 593 EP - 602 JF - Antiviral therapy JO - Antivir. Ther. (Lond.) VL - 12 IS - 4 Pt B N2 - Continuing occurrences of human infections with avian influenza A (H5N1) viruses have ignited increasing fears that the next influenza pandemic is imminent. Fortunately, options for antiviral prophylaxis and treatment have been improved dramatically since the previous pandemics by the availability of neuraminidase inhibitors such as zanamivir and oseltamivir. However, although the prophylactic and therapeutic efficacy of these drugs is well established for uncomplicated seasonal human influenza, clinical effectiveness seems limited for human H5N1 infections despite in vitro susceptibility and efficacy in animal studies. Factors which might contribute to this apparently limited efficacy include suboptimal dosing or routes of administration, suboptimal timing of treatment and the inability of antiviral drugs to interfere with immunopathology, and the development of drug resistance. Efforts to optimize the use of neuraminidase inhibitor treatment in H5N1 disease are urgently needed and might eventually aid in the judicious use of stockpiled neuraminidase inhibitors in the event of a pandemic. SN - 1359-6535 UR - https://www.unboundmedicine.com/medline/citation/17944267/Neuraminidase_inhibitors_and_their_role_in_avian_and_pandemic_influenza_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -