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Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep.
Psychoneuroendocrinology. 2007 Sep-Nov; 32(8-10):1079-85.P

Abstract

Ghrelin was shown to increase slow wave sleep (SWS) and the secretion of growth hormone (GH) and cortisol in young males. In terms of sleep, such information for females, however, is lacking. Therefore, polysomnographies were recorded (23:00-07:00 h) and nocturnal (20:00-07:00 h) secretion profiles of GH and cortisol were determined in 10 healthy females (24.9+/-2.4 years, body mass index: 21.2+/-1.1) twice, receiving four boluses of 50 microg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 h, in this single-blind, randomized, cross-over study. No significant differences of conventionally or quantitatively analyzed sleep were observed between ghrelin and placebo condition. First administration of ghrelin caused a marked mean increase of GH by 53.3 to 64.4+/-14.2 ng/ml (placebo: 5.9+/-1.5 ng/ml) and cortisol by 54.2 to 96.4+/-15.3 ng/ml (placebo: 27.5+/-4.7 ng/ml). The following ghrelin injections were associated with smaller increases of GH and cortisol. In the ghrelin condition, GH plasma levels remained significantly (P<0.05) higher from 22:20 to 02:00 h and cortisol plasma levels from 22:20 to 02:20 h. In contrast to findings in young men, ghrelin did not affect sleep in young women, indicating a sexual dimorphism. In accordance with the findings in young men, ghrelin stimulated secretion of GH and cortisol.

Authors+Show Affiliations

Max-Planck Institute of Psychiatry, Munich, Germany. kluge@mpipsykl.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17945435

Citation

Kluge, Michael, et al. "Ghrelin Enhances the Nocturnal Secretion of Cortisol and Growth Hormone in Young Females Without Influencing Sleep." Psychoneuroendocrinology, vol. 32, no. 8-10, 2007, pp. 1079-85.
Kluge M, Schüssler P, Zuber V, et al. Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. Psychoneuroendocrinology. 2007;32(8-10):1079-85.
Kluge, M., Schüssler, P., Zuber, V., Kleyer, S., Yassouridis, A., Dresler, M., Uhr, M., & Steiger, A. (2007). Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. Psychoneuroendocrinology, 32(8-10), 1079-85.
Kluge M, et al. Ghrelin Enhances the Nocturnal Secretion of Cortisol and Growth Hormone in Young Females Without Influencing Sleep. Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):1079-85. PubMed PMID: 17945435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. AU - Kluge,Michael, AU - Schüssler,Petra, AU - Zuber,Verena, AU - Kleyer,Sara, AU - Yassouridis,Alexander, AU - Dresler,Martin, AU - Uhr,Manfred, AU - Steiger,Axel, Y1 - 2007/10/22/ PY - 2007/07/30/received PY - 2007/09/03/revised PY - 2007/09/04/accepted PY - 2007/10/20/pubmed PY - 2008/3/12/medline PY - 2007/10/20/entrez SP - 1079 EP - 85 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 32 IS - 8-10 N2 - Ghrelin was shown to increase slow wave sleep (SWS) and the secretion of growth hormone (GH) and cortisol in young males. In terms of sleep, such information for females, however, is lacking. Therefore, polysomnographies were recorded (23:00-07:00 h) and nocturnal (20:00-07:00 h) secretion profiles of GH and cortisol were determined in 10 healthy females (24.9+/-2.4 years, body mass index: 21.2+/-1.1) twice, receiving four boluses of 50 microg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 h, in this single-blind, randomized, cross-over study. No significant differences of conventionally or quantitatively analyzed sleep were observed between ghrelin and placebo condition. First administration of ghrelin caused a marked mean increase of GH by 53.3 to 64.4+/-14.2 ng/ml (placebo: 5.9+/-1.5 ng/ml) and cortisol by 54.2 to 96.4+/-15.3 ng/ml (placebo: 27.5+/-4.7 ng/ml). The following ghrelin injections were associated with smaller increases of GH and cortisol. In the ghrelin condition, GH plasma levels remained significantly (P<0.05) higher from 22:20 to 02:00 h and cortisol plasma levels from 22:20 to 02:20 h. In contrast to findings in young men, ghrelin did not affect sleep in young women, indicating a sexual dimorphism. In accordance with the findings in young men, ghrelin stimulated secretion of GH and cortisol. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/17945435/Ghrelin_enhances_the_nocturnal_secretion_of_cortisol_and_growth_hormone_in_young_females_without_influencing_sleep_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(07)00210-7 DB - PRIME DP - Unbound Medicine ER -