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Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma.
Ann Oncol 2008; 19(2):242-6AO

Abstract

BACKGROUND

Radiotherapy is commonly used as a first-line treatment for localized ocular adnexal extranodal marginal zone B-cell lymphoma (EMZBL), despite its ophthalmologic complications. This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases.

PATIENTS AND METHODS

Twenty-one patients with histologically confirmed EMZBL were treated with combination of cyclophosphamide, vincristine, and prednisolone (CVP). Radiotherapy was given to CVP failure cases.

RESULTS

CVP alone resulted in overall response rate of 100% [complete remission (CR), 76.2%]. After a median follow-up of 58 months, 14 (66.7%) of 21 cases were disease free with CVP alone, while seven cases showed disease progression, including two extra-orbital and five local failures. Radiotherapy was delivered to five local failure cases, who subsequently achieved CR with late ophthalmologic complications. There were tolerable adverse events associated with CVP.

CONCLUSIONS

Front-line CVP, in conjunction with radiotherapy in recurrent cases, is effective and well tolerated in patients with localized ocular adnexal EMZBL.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17947227

Citation

Song, E-K, et al. "Efficacy of Chemotherapy as a First-line Treatment in Ocular Adnexal Extranodal Marginal Zone B-cell Lymphoma." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 19, no. 2, 2008, pp. 242-6.
Song EK, Kim SY, Kim TM, et al. Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. Ann Oncol. 2008;19(2):242-6.
Song, E. K., Kim, S. Y., Kim, T. M., Lee, K. W., Yun, T., Na, I. I., ... Heo, D. S. (2008). Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 19(2), pp. 242-6.
Song EK, et al. Efficacy of Chemotherapy as a First-line Treatment in Ocular Adnexal Extranodal Marginal Zone B-cell Lymphoma. Ann Oncol. 2008;19(2):242-6. PubMed PMID: 17947227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. AU - Song,E-K, AU - Kim,S-Y, AU - Kim,T M, AU - Lee,K-W, AU - Yun,T, AU - Na,I-I, AU - Shin,H, AU - Lee,S H, AU - Kim,D W, AU - Khwarg,S I, AU - Heo,D S, Y1 - 2007/10/17/ PY - 2007/10/20/pubmed PY - 2008/3/19/medline PY - 2007/10/20/entrez SP - 242 EP - 6 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 19 IS - 2 N2 - BACKGROUND: Radiotherapy is commonly used as a first-line treatment for localized ocular adnexal extranodal marginal zone B-cell lymphoma (EMZBL), despite its ophthalmologic complications. This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases. PATIENTS AND METHODS: Twenty-one patients with histologically confirmed EMZBL were treated with combination of cyclophosphamide, vincristine, and prednisolone (CVP). Radiotherapy was given to CVP failure cases. RESULTS: CVP alone resulted in overall response rate of 100% [complete remission (CR), 76.2%]. After a median follow-up of 58 months, 14 (66.7%) of 21 cases were disease free with CVP alone, while seven cases showed disease progression, including two extra-orbital and five local failures. Radiotherapy was delivered to five local failure cases, who subsequently achieved CR with late ophthalmologic complications. There were tolerable adverse events associated with CVP. CONCLUSIONS: Front-line CVP, in conjunction with radiotherapy in recurrent cases, is effective and well tolerated in patients with localized ocular adnexal EMZBL. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/17947227/Efficacy_of_chemotherapy_as_a_first_line_treatment_in_ocular_adnexal_extranodal_marginal_zone_B_cell_lymphoma_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdm457 DB - PRIME DP - Unbound Medicine ER -