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Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses.
J Gen Virol 2007; 88(Pt 11):3094-9JG

Abstract

Genetic analysis of all eight genes of two Nanchang avian influenza viruses, A/Duck/Nanchang/1681/92 (H3N8-1681) and A/Duck/Nanchang/1904/92 (H7N1-1904), isolated from Jiangxi province, China, in 1992, showed that six internal genes of H3N8-1681 virus and five internal (except NS gene) genes of H7N1-1904 virus were closely similar to A/Goose/Guangdong/1/96 (H5N1) virus, the first highly pathogenic avian influenza (HPAI) virus of subtype H5N1 isolated in Asia. The neuraminidase (NA) gene of Gs/Gd/1/96 had the highest genetic similarity with A/Duck/Hokkaido/55/96 (H1N1-55) virus. The haemagglutinin (HA) gene of Gs/Gd/1/96 virus might have originated as a result of mutation of H5 HA gene from A/Swan/Hokkaido/51/96 (H5N3-51)-like viruses. The PA gene of H5N3-51 virus had the highest similarity with Gs/Gd/1/96. This study explains the origin of first Asian HPAI H5N1 virus in Guangdong by the reassortment of Nanchang (close to Guangdong) and Hokkaido (Japan) (H1N1-55 and H5N3-51) viruses. Genetic characteristics of donor and recipient viruses were also studied.

Authors+Show Affiliations

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17947535

Citation

Mukhtar, Muhammad Mahmood, et al. "Origin of Highly Pathogenic H5N1 Avian Influenza Virus in China and Genetic Characterization of Donor and Recipient Viruses." The Journal of General Virology, vol. 88, no. Pt 11, 2007, pp. 3094-9.
Mukhtar MM, Rasool ST, Song D, et al. Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. J Gen Virol. 2007;88(Pt 11):3094-9.
Mukhtar, M. M., Rasool, S. T., Song, D., Zhu, C., Hao, Q., Zhu, Y., & Wu, J. (2007). Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. The Journal of General Virology, 88(Pt 11), pp. 3094-9.
Mukhtar MM, et al. Origin of Highly Pathogenic H5N1 Avian Influenza Virus in China and Genetic Characterization of Donor and Recipient Viruses. J Gen Virol. 2007;88(Pt 11):3094-9. PubMed PMID: 17947535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. AU - Mukhtar,Muhammad Mahmood, AU - Rasool,Sahibzada T, AU - Song,Degui, AU - Zhu,Chengliang, AU - Hao,Qian, AU - Zhu,Ying, AU - Wu,Jianguo, PY - 2007/10/20/pubmed PY - 2007/12/7/medline PY - 2007/10/20/entrez SP - 3094 EP - 9 JF - The Journal of general virology JO - J. Gen. Virol. VL - 88 IS - Pt 11 N2 - Genetic analysis of all eight genes of two Nanchang avian influenza viruses, A/Duck/Nanchang/1681/92 (H3N8-1681) and A/Duck/Nanchang/1904/92 (H7N1-1904), isolated from Jiangxi province, China, in 1992, showed that six internal genes of H3N8-1681 virus and five internal (except NS gene) genes of H7N1-1904 virus were closely similar to A/Goose/Guangdong/1/96 (H5N1) virus, the first highly pathogenic avian influenza (HPAI) virus of subtype H5N1 isolated in Asia. The neuraminidase (NA) gene of Gs/Gd/1/96 had the highest genetic similarity with A/Duck/Hokkaido/55/96 (H1N1-55) virus. The haemagglutinin (HA) gene of Gs/Gd/1/96 virus might have originated as a result of mutation of H5 HA gene from A/Swan/Hokkaido/51/96 (H5N3-51)-like viruses. The PA gene of H5N3-51 virus had the highest similarity with Gs/Gd/1/96. This study explains the origin of first Asian HPAI H5N1 virus in Guangdong by the reassortment of Nanchang (close to Guangdong) and Hokkaido (Japan) (H1N1-55 and H5N3-51) viruses. Genetic characteristics of donor and recipient viruses were also studied. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/17947535/Origin_of_highly_pathogenic_H5N1_avian_influenza_virus_in_China_and_genetic_characterization_of_donor_and_recipient_viruses_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.83129-0 DB - PRIME DP - Unbound Medicine ER -