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A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia.
Psychol Med. 2008 Jun; 38(6):877-85.PM

Abstract

BACKGROUND

Diffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia.

METHOD

Subjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership.

RESULTS

In patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls.

CONCLUSIONS

Widespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness.

Authors+Show Affiliations

Department of Psychiatry, The University of Hong Kong, and Queen Mary Hospital, Pokfulam, Hong Kong, S.A.R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17949516

Citation

Cheung, V, et al. "A Diffusion Tensor Imaging Study of Structural Dysconnectivity in Never-medicated, First-episode Schizophrenia." Psychological Medicine, vol. 38, no. 6, 2008, pp. 877-85.
Cheung V, Cheung C, McAlonan GM, et al. A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychol Med. 2008;38(6):877-85.
Cheung, V., Cheung, C., McAlonan, G. M., Deng, Y., Wong, J. G., Yip, L., Tai, K. S., Khong, P. L., Sham, P., & Chua, S. E. (2008). A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychological Medicine, 38(6), 877-85.
Cheung V, et al. A Diffusion Tensor Imaging Study of Structural Dysconnectivity in Never-medicated, First-episode Schizophrenia. Psychol Med. 2008;38(6):877-85. PubMed PMID: 17949516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. AU - Cheung,V, AU - Cheung,C, AU - McAlonan,G M, AU - Deng,Y, AU - Wong,J G, AU - Yip,L, AU - Tai,K S, AU - Khong,P L, AU - Sham,P, AU - Chua,S E, Y1 - 2007/10/22/ PY - 2007/10/24/pubmed PY - 2008/10/8/medline PY - 2007/10/24/entrez SP - 877 EP - 85 JF - Psychological medicine JO - Psychol Med VL - 38 IS - 6 N2 - BACKGROUND: Diffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia. METHOD: Subjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership. RESULTS: In patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls. CONCLUSIONS: Widespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness. SN - 0033-2917 UR - https://www.unboundmedicine.com/medline/citation/17949516/A_diffusion_tensor_imaging_study_of_structural_dysconnectivity_in_never_medicated_first_episode_schizophrenia_ L2 - https://www.cambridge.org/core/product/identifier/S0033291707001808/type/journal_article DB - PRIME DP - Unbound Medicine ER -