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Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique.
Eur J Pharm Biopharm. 2008 May; 69(1):342-7.EJ

Abstract

The aim of the work was to improve the dissolution properties of the practically insoluble antiepileptic drug, Carbamazepine (CBZ) by adopting the liquisolid compaction technique. Reported liquid load factors, and excipient ratios were used to calculate the required amounts of excipients necessary to prepare the compacts or tablets according to a mathematical model. Avicel PH 102, and Aerosil 200 were used as the carrier and the coating materials, respectively, and explotab was used as disintegrant to prepare four tablet formulae, out of which formula 1 was successfully compressed into tablets. The dissolution patterns of liquisolid CBZ tablets, carried out according to the USP, were comparable to those of Tegretol. The protection of male albino mice against the convulsion, induced by electroshock, was lower in case of liquisolid tablets compared to Tegretol suspension and tablets probably due to the precipitation of CBZ in the silica pores resulting from its high dose.

Authors+Show Affiliations

Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17949959

Citation

Tayel, Saadia A., et al. "Improvement of Dissolution Properties of Carbamazepine Through Application of the Liquisolid Tablet Technique." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 69, no. 1, 2008, pp. 342-7.
Tayel SA, Soliman II, Louis D. Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique. Eur J Pharm Biopharm. 2008;69(1):342-7.
Tayel, S. A., Soliman, I. I., & Louis, D. (2008). Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 69(1), 342-7.
Tayel SA, Soliman II, Louis D. Improvement of Dissolution Properties of Carbamazepine Through Application of the Liquisolid Tablet Technique. Eur J Pharm Biopharm. 2008;69(1):342-7. PubMed PMID: 17949959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique. AU - Tayel,Saadia A, AU - Soliman,Iman I, AU - Louis,Dina, Y1 - 2007/09/18/ PY - 2007/06/23/received PY - 2007/08/10/revised PY - 2007/09/10/accepted PY - 2007/10/24/pubmed PY - 2008/8/12/medline PY - 2007/10/24/entrez SP - 342 EP - 7 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 69 IS - 1 N2 - The aim of the work was to improve the dissolution properties of the practically insoluble antiepileptic drug, Carbamazepine (CBZ) by adopting the liquisolid compaction technique. Reported liquid load factors, and excipient ratios were used to calculate the required amounts of excipients necessary to prepare the compacts or tablets according to a mathematical model. Avicel PH 102, and Aerosil 200 were used as the carrier and the coating materials, respectively, and explotab was used as disintegrant to prepare four tablet formulae, out of which formula 1 was successfully compressed into tablets. The dissolution patterns of liquisolid CBZ tablets, carried out according to the USP, were comparable to those of Tegretol. The protection of male albino mice against the convulsion, induced by electroshock, was lower in case of liquisolid tablets compared to Tegretol suspension and tablets probably due to the precipitation of CBZ in the silica pores resulting from its high dose. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/17949959/Improvement_of_dissolution_properties_of_Carbamazepine_through_application_of_the_liquisolid_tablet_technique_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(07)00304-9 DB - PRIME DP - Unbound Medicine ER -