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Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions.
Gynecol Oncol 2007; 107(2):159-62GO

Abstract

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast/Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk ovarian cancer. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2 or MSH6, associated with the Lynch/Hereditary Non-Polyposis Colorectal Cancer (HNPCC) syndrome, have up to a 40-60% lifetime risk of both endometrial and colorectal cancer as well as a 9-12% lifetime risk of ovarian cancer. Genetic risk assessment enables physicians to provide individualized evaluation of the likelihood of having one of these gynecologic cancer predisposition syndromes, as well the opportunity to provide tailored screening and prevention strategies such as surveillance, chemoprevention, and prophylactic surgery that may reduce the morbidity and mortality associated with these syndromes. Hereditary cancer risk assessment is a process that includes assessment of risk, education and counseling conducted by a provider with expertise in cancer genetics, and may include genetic testing after appropriate consent is obtained. This commentary provides guidance on identification of patients who may benefit from hereditary cancer risk assessment for Hereditary Breast/Ovarian Cancer and the Lynch/Hereditary Non-Polyposis Colorectal Cancer syndrome.

Pub Type(s)

Journal Article
Practice Guideline
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17950381

Citation

Lancaster, Johnathan M., et al. "Society of Gynecologic Oncologists Education Committee Statement On Risk Assessment for Inherited Gynecologic Cancer Predispositions." Gynecologic Oncology, vol. 107, no. 2, 2007, pp. 159-62.
Lancaster JM, Powell CB, Kauff ND, et al. Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol. 2007;107(2):159-62.
Lancaster, J. M., Powell, C. B., Kauff, N. D., Cass, I., Chen, L. M., Lu, K. H., ... Herzog, T. J. (2007). Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecologic Oncology, 107(2), pp. 159-62.
Lancaster JM, et al. Society of Gynecologic Oncologists Education Committee Statement On Risk Assessment for Inherited Gynecologic Cancer Predispositions. Gynecol Oncol. 2007;107(2):159-62. PubMed PMID: 17950381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. AU - Lancaster,Johnathan M, AU - Powell,C Bethan, AU - Kauff,Noah D, AU - Cass,Ilana, AU - Chen,Lee-May, AU - Lu,Karen H, AU - Mutch,David G, AU - Berchuck,Andrew, AU - Karlan,Beth Y, AU - Herzog,Thomas J, AU - ,, PY - 2007/09/18/received PY - 2007/09/19/accepted PY - 2007/10/24/pubmed PY - 2007/12/13/medline PY - 2007/10/24/entrez SP - 159 EP - 62 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 107 IS - 2 N2 - Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast/Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk ovarian cancer. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2 or MSH6, associated with the Lynch/Hereditary Non-Polyposis Colorectal Cancer (HNPCC) syndrome, have up to a 40-60% lifetime risk of both endometrial and colorectal cancer as well as a 9-12% lifetime risk of ovarian cancer. Genetic risk assessment enables physicians to provide individualized evaluation of the likelihood of having one of these gynecologic cancer predisposition syndromes, as well the opportunity to provide tailored screening and prevention strategies such as surveillance, chemoprevention, and prophylactic surgery that may reduce the morbidity and mortality associated with these syndromes. Hereditary cancer risk assessment is a process that includes assessment of risk, education and counseling conducted by a provider with expertise in cancer genetics, and may include genetic testing after appropriate consent is obtained. This commentary provides guidance on identification of patients who may benefit from hereditary cancer risk assessment for Hereditary Breast/Ovarian Cancer and the Lynch/Hereditary Non-Polyposis Colorectal Cancer syndrome. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/17950381/Society_of_Gynecologic_Oncologists_Education_Committee_statement_on_risk_assessment_for_inherited_gynecologic_cancer_predispositions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(07)00789-5 DB - PRIME DP - Unbound Medicine ER -